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Recent progress in CAR-T cell therapy for B-cell cancers with resistant tissues
(Academic Press, 2026) Rajesh Kumar , Seetha Harilal , Mohd Aftab Siddiqui , Mohhammad Ramzan , Sumel Ashique
The therapy of B-cell cancers, particularly lymphomas, has undergone a tremendous change with the approval of chimeric antigen receptor (CAR)-T cell therapy, and is currently widely available, which can be considered as a standard therapeutic option, in the case of patients having aggressive lymphomas, even though being utilized after multiple lines of treatment. The current CAR-T cell therapies, which are approved by the FDA works by targeting the antigens such as CD19 or BCMA present in the B cells. The CAR-T cell therapies are rapidly advancing with new findings to address the current limitations, including toxicities, and resistance; such as targeting multiple antigens, the source and the delivery of genetic material into the T cells, utilization of nanotechnology, as well as mRNA-based strategies, utilization of another type of immune cells such as the natural killer cells, as well as incorporating gene editing strategies. A large number of studies, including preclinical and clinical trials, are conducted to translate the findings from the bench to the bedside. The chapter discusses the CAR-T cell therapy, the mechanism, approved therapies, limitations, including toxicities, and resistance, and recent advancements in research, particularly in the therapy of B-cell cancers.
Efficient Removal of Methylene Blue Dye from Textile Industry Effluent Using Rice Husk Peanut Shell Biochar: Adsorption Studies, Isotherm Profiling, and Kinetics Analysis
(Springer, Singapore, 2026) Neha Mumtaz, Tabish Izhar, Syed Aqeel Ahmad, Md. Jamshaid
Agricultural byproducts like rice husks and peanut shells are widely accessible. Rice Husk Peanut Shell Biochar (RHPSB), a new bio-adsorbent, is used in this study to remove methylene blue dye from the textile industry effluent. This minimizes the environmental impact of waste disposal. The biochar was synthesized through pyrolysis, a relatively low-cost and energy-efficient process in a muffle furnace at 500 °C. A reactor containing an aqueous solution of MB dye (50 ml) was loaded with the desired concentration (0.25, 0.50, 0.75, 1.5, 3.0 gm/50 ml) of RHPSB powder, and adsorption was facilitated. The mixture was incubated at room temperature in an incubator shaker at 120 rpm until equilibrium was reached. The pH level was kept constant at 8.3. The removal efficiencies of MB by RHPSB in a batch experiment were 73.0–98.9% at conditions, pH (6.0–11.0); Biochar dosage (0.5–6.0 g/100 mL) for 5 days. Thus, RHPSB is a more effective adsorbent for dye removal. Isotherm profiling, Adsorption kinetics, and Morphological Analysis by Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) were also done to ensure the efficiency of the biochar. The PHz value was 7.8 for the RHPSB. The best adsorption isotherm and kinetics data best matched for Langmuir (R2 0.9981) and pseudo-second-order equation (R2 0.9986). The results of this study demonstrate that RHPSB is a highly effective adsorbent for the removal of methylene blue dye from textile industry effluent, opening up intriguing possibilities for long-term and sustainable wastewater treatment solutions.
Empowering water security: the synergy of automation and IoT integration
(Elsevier, 2025) Neha Mumtaz, Tabish Izhar, Jazbi Izhar, Syed Aqeel Ahmad
The integration of automation and the Internet of Things (IoT) is revolutionizing water security by combining smart sensors, data analytics, and automated systems within water management frameworks. This integration addresses challenges such as water scarcity, quality assurance, efficient resource utilization, and infrastructure resilience. Key benefits include real-time monitoring and control, data-driven decision making, resource optimization, and enhanced safety. IoT sensors provide continuous data streams, enabling proactive interventions and minimizing risks. Automated systems adjust water usage and optimize processes, leading to cost savings and environmental benefits. However, challenges like data security, interoperability, scalability, and the role of human operators must be addressed. Future advancements in AI, machine learning, blockchain, edge computing, and collaborative platforms promise to enhance these integrated solutions further, driving innovation, resilience, and sustainability in water management.
Synthetic Innovations: Engineering Solutions in Diabetes
(Apple Academic Press (CRC Press), 2026) Wan Nurhidayah Wan Hanaffi, Nazish Naseem, Usama Ahmad, Anas Islam, and Mohd. Muazzam Khan
The global increase in diabetes incidence necessitates the investigation of innovative management strategies for this chronic illness. Advances in synthetic innovations are crucial to address the complexities of diabetes treatment. The convergence of synthetic biology and engineered biological systems has fostered novel therapeutic methods, particularly for insulin administration and glucose management. Key innovations include engineered cells, encapsulation techniques, and biohybrid devices that enhance diabetes management while minimizing the frequency of insulin injection. These synthetic advancements are transforming diabetes care by designing biological systems for specific functions, such as insulin release in response to glucose levels. This domain has the capacity to develop advanced therapies that replicate natural glucose regulation by pancreatic β-cells, thereby offering an alternative to conventional treatment methods. Significant progress has been made in glucose-responsive synthetic systems and nanomedicines that regulate insulin release according to glucose elevation, emulating β-cell functionality. These novel approaches promise to enhance the quality of life of patients with diabetes by facilitating natural glucose control.
Emerging Trends in Advanced Material & Applications
(Book Rivers, 2026) Sumita Chaturvedi, Mohd Faizan Hasan, Shahnawaz Alam