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Antibody-drug conjugates in breast cancer treatment
(Elsevier (Academic Press), 2026) Joy Das, Utpal Bhui, Anish Singh, Lovedeep Singh, Amit Chakraborty, Anas Islam, Mayukh Jana
Antibody-drug conjugates (ADCs) represent a rapidly advancing therapeutic strategy that has significantly expanded treatment options for breast cancer by uniting highly specific antibody targeting with the cell-killing capacity of cytotoxic agents. This chapter systematically examines the scientific foundation and clinical relevance of ADCs, beginning with their structural design, key components, and mechanisms of action within cancer cells. Major molecular targets in breast cancer, including human epidermal growth factor receptor 2 (HER2), TROP-2, and emerging biomarkers, are discussed in relation to tumor biology and target selection criteria. The chapter further reviews clinically approved ADCs, evaluates comparative clinical outcomes, and summarizes ongoing clinical development efforts, with particular attention to HER2-low and triple-negative breast cancer. Pharmacokinetic and pharmacodynamic characteristics, resistance mechanisms, and safety considerations are critically addressed to highlight factors influencing therapeutic success and limitations. Recent technological advances in ADC design, such as improved conjugation methods and novel payload strategies, are also explored. Overall, this chapter discusses the current status, challenges, and future directions of ADCs in breast cancer, emphasizing their growing role in personalized therapy, rational drug design, and integrated treatment approaches.
Yoga and the Environment: A Holistic Approach
(Book Rivers, 2026) Shweta Yadav
Yoga, an ancient Indian practice, promotes oneness not only of body, mind, and spirit but also with nature and the surrounding ecology. The principles of balance, interaction, and harmony are essential for the relationship between yoga and the environment. In today's fast-paced world, lifestyle disorders have become a significant concern, requiring individuals to make conscious changes to their daily habits. (Rashmi Gopal Untwal *, 2025) Yoga and spirituality are essential components in managing these disorders. Since environmental issues across the globe increase, yoga's broad philosophy provides timeless insight concerning how to live mindfully and sustainably. Yoga assists relationships develop more mindful of their own health, other individuals, and their surroundings. People can embrace simpler, more sustainable existences, preserve natural resources, and make eco-friendly decisions as a consequence of this raised awareness. This chapter addresses how yoga could foster ecological awareness and responsibility while exploring the relation between yogic ideology and preservation of the environment. The relationship between yoga and environmental sustainability shows the growing importance of integrating traditional wisdom into ecological thinking. Yogic philosophy emphasizes the oneness and connectivity of all living things by means of ideas like Ahimsa, Aparigraha, and Santosha.
Transcription factors in regulating the synthesis of secondary metabolites in plants
(Academic Press (Elsevier), 2027) Aisha Kamal, Garvit Verma, Sanaya, Nida Sultan, Sazia Siddiqui, Ayeesha Khatoon
Diagnostic Modalities and Holistic Management Strategies for Diabetes
(CRC Press (Taylor & Francis Group), 2026) Mohd. Mursal, Mohammad Ahmad, Deeba Shamim Jairajpuri, Asad Ahmad
Revolutionizing Diabetes Care with Nanotechnology Innovations
(CRC Press (Taylor & Francis Group), 2026) Purba Mandal, Aditya Singh, Juber Akhtar, Perwez Alam