Browsing by Author "Kuldeep Singh"

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    Outer Membrane Permeability Enhancer
    (IGI Global, 2024) Kuldeep Singh; Mo Shahanawaz,Shom Prakash Kushwaha, Arun Kumar, Suvaiv, Shafiurrahma
    Bacterial resistance poses a significant threat to global healthcare systems and requires innovative solutions to combat this growing problem. In this context, the concept of outer membrane permeability enhancers has emerged as a promising strategy. The gram-negative bacteria's outer membrane acts as a robust defense mechanism, limiting the effectiveness of antibiotics. The introduction of outer membrane permeability enhancers aims to address this challenge by enhancing the permeability of the outer membrane, thus facilitating the entry of antibiotics into bacterial cells. In this chapter, the authors explore the intricacies of outer membrane permeability enhancers like EDTA, polymyxins, aminoglycosides, and tris or tris (hydroxymethyl) aminomethane and their potential impact on bacterial resistance. The outer membrane's composition, comprising lipopolysaccharides, proteins, and phospholipids, creates a formidable barrier that many antibiotics struggle to penetrate.
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    Targeted Drug Delivery to Combat Antibacterial Drug Resistance
    (IGI Global, 2024) Kuldeep Singh; Nitin Pandey,Shom Prakash Kushwaha, Arun Kumar, Mohammad Khalid, Ahsan Ahmed Khan, Maaz Khan
    In targeted drug delivery, antibiotics are precisely delivered to infection areas using nanoparticles and carrier systems, increasing effectiveness, lowering side effects, and causing the least amount of damage to the microbiota. By increasing local antibiotic concentrations, releasing antibiotics selectively depending on bacterial indicators, and using synergistic combination treatments, this approach combats antibacterial resistance. Diagnostics, real-time monitoring, and responsive medication delivery are all combined on multifunctional platforms made possible by nanotechnology. Though problems like biocompatibility and regulatory barriers still exist, recent research has shown promise both in vitro and in vivo. Targeted drug delivery, subject to additional study and invention, offers a method to increase antibiotic effectiveness while tackling resistance. It promises to improve the management of infectious diseases. Targeted distribution can address a variety of problems related to antibacterial resistance.