Browsing by Author "Mohd Akil, Iqbal Azad, Abdul Rahman Khan, Naseem Ahmad"

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    Synthesis and in silico Analysis of 4,5-dihydro-1H-pyrazole derivative
    (Tashkent Institute of Chemical Technology, 2026) Mohd Akil, Iqbal Azad, Abdul Rahman Khan, Naseem Ahmad
    The present work reports the synthesis of novel chalcone‐derived compounds obtained via simple condensation of chalcone derivatives with phenyl hydrazine. Their design, preparation, and biological assessment are described in detail. Structural elucidation was confirmed by FTIR, 1H NMR, 13C NMR, and HRMS analyses. In‐silico ADMET profiling, carried out using AdmetLab 3.0 and SwissADME, indicated favorable pharmacokinetic and toxicity parameters, closely resembling those of reference agents Amphotericin B and Ciprofloxacin. These findings underscore the promise of chalcone scaffolds as versatile templates for antibacterial drug development.