Browsing by Author "Sana Parveen, Mariyam Fatma, Snober S. Mir"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Integrating Tradition and Innovation: The Role of Withania somnifera in Cancer Therapeutics
    (Book Rivers, 2026) Sana Parveen, Mariyam Fatma, Snober S. Mir
    Medicinal plants have been integral to healing in local communities for thousands of years and are crucial for approximately 85% of the global population. They are also a major source of drug discovery, with 80% of synthetic drugs deriving from them. Withania somnifera (WS), a prominent Rasayana botanical in Ayurveda, is renowned for its immunomodulatory, anti-aging, adaptogenic, and rejuvenating effects. WS exhibits therapeutic potential in cancer management due to its diverse biological activities. Major Phytoconstituent of WS like Withaferin-A (Wi-A) and Withanone has shown notable anticancer properties. Phytoconstituents of WS also have the potential to induce cell cycle arrest by downregulating cyclin B1, cyclin A, Cdk2, and p-Cdc2, while increasing p-Chk1 and p-Chk2 levels. It also affects HPV E6 and E7 oncoproteins, accumulates p53, and enhances p21WAF1 levels. Additionally, decreases STAT3 levels, promotes p53-mediated apoptosis (increasing Bcl2, Bax, caspase-3, cleaved PARP, and Par-4), and disrupts AKT and EMT signaling. These findings underline WS potential as a natural anticancer agent, with reported effects across various cancer types, including oxidative stress-induced mitochondrial dysfunction leading to programmed cell death.