Browsing by Author "Sayyeda Rushan, Saimah Khan"

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ADVANCES IN PYRAZOLE DERIVED MOLECULES AS ANTI-CANCER AGENTS
(Liberty Publishing House, 2026) Sayyeda Rushan, Saimah Khan
Pyrazole-derived molecules have gained considerable attention in recent years as promising candidates in anticancer drug discovery due to their structural diversity and wide-ranging biological activities. This study highlights recent advances in the design, synthesis, and biological evaluation of pyrazole-based compounds as antitumor agents. The pyrazole scaffold serves as a versatile pharmacophore capable of interacting with multiple molecular targets involved in cancer progression, including cyclin-dependent kinases, tyrosine kinases, and topoisomerases'. These compounds exhibit significant anticancer activity through mechanisms such as induction of apoptosis, inhibition of cell proliferation, suppression of angiogenesis, and modulation of inflammatory pathways. Recent studies emphasize the importance of structure-activity relationship (SAR) analysis, where strategic substitution and hybridization with other bioactive moieties have led to enhanced potency and selectivity against various cancer cell lines. Furthermore, advancements in drug design approaches, including molecular docking and nanotechnology-based delivery systems, have improved the therapeutic potential of pyrazole derivatives. Although encouraging results have been observed in preclinical studies, several challenges such as toxicity, limited bioavailability, and hurdles in clinical translation still need to be addressed. Nevertheless, pyrazole-derived molecules continue to represent a rapidly evolving and promising class of compounds with substantial potential for the development of effective and targeted anticancer therapies.
GREEN SYNTHESIS OF PYRAZOLE
(Tashkent Institute of Chemical Technology, 2026) Sayyeda Rushan, Saimah Khan
Heterocyclic rings named pyrazole-containing compounds show a significant role in medicinal chemistry, owing to various FDA-approved drugs that are used in the treatment of carcinomas as well. Such a five-membered ring has different conformations through their active sites that interact with the targeted amino acid residues and consequently show good inhibition against targeted proteins. Green chemistry is an interdisciplinary field that focuses on minimizing hazardous substances and promoting sustainable alternatives in chemical processes to conventional chemical processes and products. This review provides a comprehensive analysis of the fundamental principles, historical development, and practical applications of green chemistry with a particular emphasis on its role in advancing sustainable chemical synthesis, analytical methodologies, and industrial practices. Chemists availed synthesis to the discovery of drugs using a chemically reaction-based strategy. For that, the analytical techniques named FT-IR, 1H NMR and 13C NMR spectroscopic were applied to the molecular structure’s evaluation. Not only that, but ESI-MS/HRMS spectrometry tools have an important role for the confirmation of synthesized compounds. The various methods for drug discovery are used, like in silico, in vitro and in vivo analyses, to find their biological effects against the targeted proteins. The aim of this research is the discovery of pyrazole-containing drugs that could be used in the treatment of various carcinomas.