Browsing by Author "Umme Habiba Malika, Ayesha Anwera, Mohammad Amira, Malik Nasibullaha"

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    Synthesis, and Computational Studies of Methyl 6’ -AMINO-5’-CYANO-2-OXO-2’H- SPIRO[INDOLINE-3’4’- PYRANO(2,3-C) PYRAZOLE]-3’-CARBOXYLATE
    (Book Rivers, 2026) Umme Habiba Malika, Ayesha Anwera, Mohammad Amira, Malik Nasibullaha
    Pyrazole derivatives are important heterocyclic compounds known for their wide range of biological activities, including antibacterial, antifungal, anti-inflammatory, analgesic, anticancer, and antidiabetic properties. In this study, a novel spiro pyranopyrazole derivative, methyl 6'-amino-5'-cyano-2-oxo-2'H-spiro[indoline-3,4'-pyrano[2,3-c]pyrazole]-3'-carboxylate, was synthesized through a one-pot multicomponent reaction using dimethyl acetylene dicarboxylate (DMAD), hydrazine monohydrate, malononitrile, and isatin in PEG:EtOH medium with TBAI as a catalyst at room temperature. The synthesized compound was obtained in good yield and characterized by spectroscopic methods. Pharmacokinetic and ADMET studies indicated favourable drug-likeness, oral bioavailability, and acceptable absorption properties according to Lipinski's rule of five. Biological activity prediction also suggested promising pharmacological potential.