Research Articles/ Conferences
Permanent URI for this collectionhttp://192.168.24.11:4000/handle/123456789/58
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Item Synthesis, Characterization and Anticancer Evaluations of Novel Bromobiphenyl Imidazole Chalcone(Tashkent Institute of Chemical Technology, 2026) Jaya Gupta Mohd, Arsh Khan, Firoj HassanLung cancer remains a major global health challenge and is a leading cause of cancer-related mortality, highlighting the need for novel therapeutic agents. In this study, a new bromobiphenyl-imidazole chalcone derivative, (E)-1-(4′-bromo-[1,1′-biphenyl]-4- yl)-3-(1H-imidazol-4-yl)prop-2-en-1-one, was synthesized through a Claisen–Schmidt condensation reaction and evaluated for its anticancer activity against A549 cells. The synthesized compound was obtained in good yield and subsequently subjected to biological evaluation. Cytotoxicity studies revealed that the compound exhibited significant dose-dependent inhibition of A549 cell growth with an IC50 value of 21.06μg/mL, indicating promising anticancer potential. Further mechanistic investigations demonstrated enhanced intracellular ROS generation and induction of nuclear condensation, suggesting apoptosis-mediated cell death as a possible mode of action. The observed biological activity may be attributed to the combined presence of bromobiphenyl and imidazole pharmacophores within the conjugated chalcone framework, which promotes molecular planarity, electron delocalization, and favourable interactions with cellular targets.Item Comparative Investigation of TiO2, CuS and TiO2/CuS Nanomaterials Toward Efficient Solar Energy Harvesting(Tashkent Institute of Chemical Technology, 2026) Kishor Nand, Mohd Arsh Khan, Firoj Hassan, Md. Rashid TanveerThe synthesis, characterization and optimization of TiO2, CuS and TiO2/CuS composite nanomaterials for enhancing solar energy conversion efficiency was investigated. TiO2 nanomaterials were developed using sol-gel method. CuS nanomaterials were synthesized using hydrothermal method. Then TiO2/CuS composite nanomaterials were synthesized. These samples were analysed for their electrochemical, optical, morphological and structural properties. X-ray diffraction and field emission scanning electron microscopy confirmed the successful formation of desired crystal phases and surface morphologies. Optical characterization revealed promising band gap energies and light absorption capabilities while electrochemical tests indicated improved photoactivity and stability. The comparative study of TiO2, CuS and TiO2/CuS composite nanomaterials shows improved results in the composite form.Item Purine Derivatives in Medicinal Chemistry: Design, Synthesis, and Application in Cancer Treatment(Zenodo, 2026) Fiza Farooqui, Anam Saleem, Abdul Rahman Khan, Malik Nasibullah, Jamal Akhtar AnsariMany often-used anti-cancer medications are based on heterocyclic compounds, which are fundamental to modern medicinal chemistry. Among these are purine derivatives, which are becoming well-known because of their structural resemblance to natural nucleo bases. This likeness lets them interface with biological targets promoting cancer development. Purine-based substances have shown great anticancer potential in studies on breast cancer by affecting key cellular processes including signal transduction, cell cycle control, programmed cell death, and neovascularization. By precisely altering the purine structure at sites such C-6, N-9, and C-8, new derivatives and hybrid compounds with superior activity, selectivity, and suitable drug-like properties have been created. These substances finally restrict the development and spread of tumor cells by targeting vital molecular targets including heat shock proteins, cyclin-dependent kinases, and enzymes engaged in purine synthesis. Several purine derivatives in particular have shown amazing efficacy against aggressive and therapy-resistant types of breast cancer including triple-negative breast cancer.Item Mucuna Pruriens Chemical Constituents as Potent Male Anti- Infertility Agent(Zenodo, 2026) Anam Saleem, Abdul Rahman Khan, Jamal Akhtar AnsariThe inability of a couple to conceive even after a year of frequent unprotected sexual activity is commonly referred to as infertility. The decline in male reproductive efficacy is increasingly attributed to molecular imbalances within the hypothalamic-pituitary-gonadal (HPG) axis and the accumulation of oxidative stressors. While synthetic interventions are available current chemical research is pivoting toward natural product scaffolds for their multi target functionality. Among these Mucuna pruriens stands out due to its high concentration of L-DOPA (L-3,4- dihydroxyphenylalanine), a non-protein amino acid that serves as a critical biochemical precursor to dopamine. This abstract examines the chemical mechanisms by which M. pruriens constituents mitigate infertility by modulating steroidogenesis and neutralizing reactive oxygen species (ROS). The therapeutic efficacy of Mucuna pruriens is primarily driven by the structural bioavailability of its L-Dopa content. Chemically L-Dopa crosses the blood brain barrier and undergoes decarboxylation to dopamine which inhibits the release of prolactin, a peptide hormone that in excess, suppresses testosterone biosynthesis. By maintaining the chemical homeostasis of dopamine Mucuna extracts facilitate the upregulation of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). Furthermore, phytochemical screening of Mucuna seeds reveals a complex matrix of alkaloids polyphenols and tocopherols. These molecules possess high electron donating potential allowing them to scavenge hydroxyl and superoxide radicals within the seminal environment thereby protecting the integrity of the sperm's polyunsaturated fatty acid (PUFA) membranes from lipid peroxidation. To ensure clinical reproducibility analytical standardization of these extracts is paramount. Advanced techniques such as Reverse-Phase High-Performance Liquid Chromatography (RP- HPLC) are utilized to quantify L-Dopa levels often using a mobile phase of dilute phosphoric acid or methanol to achieve sharp peak resolution. Additionally Liquid Chromatography-Mass Spectrometry (LC-MS/MS) is employed to map the broader "chemical fingerprint" of the seed, identifying secondary metabolites that may act synergistically with L-Dopa to enhance its stability. In conclusion, the integration of Mucuna pruriens into fertility treatments represents a sophisticated application of bio-organic chemistry where specific plant derived molecular structures are leveraged to restore systemic hormonal balance and protect cellular DNA.Item CU-TCCP Metal–Organic Framework as a Selective and Recyclable Sensor for Acetone Detection(Tashkent Institute of Chemical Technology, 2026) Shumaila Suhaila, Naseem Ahmada, Nafees AhmadaMetal–organic frameworks (MOFs) have emerged as versatile porous materials with tunable structures and functionalities for chemical sensing applications. The present study deal with a copper-based MOF, Cu-TCCP, synthesized using 1,2,4,5-tetrakis (4- carboxyphenyl) benzene (TCCP) as an organic linker, is investigated for the selective sensing of acetone. Acetone, a volatile organic compound (VOC), is of great concern due to its role as an environmental pollutant and a biomarker in medical diagnostics, particularly for diabetes monitoring. The Cu-TCCP framework exhibits a highly ordered porous structure with abundant Lewis acid sites, facilitating strong host–guest interactions with the carbonyl functional group of acetone. Structural stability, large surface area, and uniform pore channels contribute to rapid adsorption and signal response. Spectroscopic and adsorption studies confirm that Cu-TCCP demonstrates excellent selectivity toward acetone. The sensing mechanism is attributed to synergistic π–π stacking, hydrogen bonding, and Cu–O coordination, leading to detectable changes in CV curve. Furthermore, the Cu-MOF shows good recyclability and stability under repeated sensing cycles, highlighting its potential as a reusable sensor platform. These findings suggest that Cu-TCCP can serve as an efficient MOF-based sensor for real-time acetone monitoring, with promising applications in environmental remediation, industrial safety, and non-invasive medical diagnostics.Item Design of Spinel Nanomaterials for Photocatalytic Degradation of Water Contaminants(Tashkent Institute of Chemical Technology, 2026) Sana Nisar, Naseem Ahmed, Nafees AhmedWater contamination caused by industrialization, urbanization, and agricultural activities has emerged as a major global environmental challenge. The presence of persistent organic pollutants, dyes, pharmaceuticals, pesticides, and heavy metals in aquatic systems poses serious risks to both human health and ecosystems. Among various wastewater treatment technologies, photocatalysis has gained significant attention as an environmentally friendly and sustainable approach for the degradation and mineralization of water contaminants. In recent years, spinel nanomaterials with the general formula MFe2O4 (M = Co, Ni, Zn, Mn, Mg, Cu, etc.) have emerged as promising photocatalysts owing to their unique structural, optical, magnetic, and electronic properties. Their narrow band gaps, high chemical stability, facile magnetic recovery and tunable surface characteristics make them suitable candidates for visible-light-driven photocatalytic applications. This review provides a comprehensive overview of the design strategies employed to enhance the photocatalytic performance of spinel nanomaterials for water purification. Particular emphasis is placed on the degradation mechanisms of various water contaminants, including organic dyes, pharmaceutical residues, pesticides, and emerging pollutants under UV and visible-light irradiation. This review aims to provide valuable insights into the rational design of next-generation spinel photocatalysts for effective remediation of water contaminants.Item Green-Synthesis of ZnO Nanostructures Using Aqueous Leaves Extract of Rosa Indica: Photocatalytic Under Solar Light Irradiation(Tashkent Institute of Chemical Technology, 2026) Suneel, Mohd Shabbirb, Qazi InamurRahmanRecent studies have demonstrated a dramatic escalation in global water consumption, with an approximate 600% increase over the past century. Due to the expansion of textile, there is a release of synthetic organic dye effluents, which are contributing to the deterioration of water quality, rendering it unsuitable for potable use, posing significant threats to both human health and aquatic ecosystems. Notably, the textile sector alone utilizes approximately. 100,000 metric tons of dyes annually, with approximately 15% of these chromophonic compounds being inappropriately discharged into aquatic environments and surface water systems. Green- synthesised zinc oxide (ZnO) has emerged as a competitive photocatalyst due to its superior electron mobility.Item G-C3N4/TIO2 Composite for Efficient Photocatalytic Degradation of Organic Pollutants Under Visible Light Illumination(Tashkent Institute of Chemical Technology, 2026) Neda Tabassum, Zeba Ali Mumtaj, QaziInamurRahmanA novel pathway for effective environmental remediations has recently been opened by the combination of TiO2 and graphitic carbon nitride (g-C3N4).With varying g-C3N4 compositions, TiO2 characteristics namely its optical band gap energy and ability to collect visible light irradiations while being unable to do so on its own fluctuate dramatically. In addition, the g-C3N4/TiO2 composite improves stability, porosity and electron mobility. The purity and crystallinity of the composite are analyzed using several analytical techniques such as X-ray diffraction Energy dispersive spectroscopy and Fourier transform infrared spectroscopy, while the shape of the composite is revealed by SEM and TEM. The fabrication of the g-C3N4/TiO2 composite which may simplify the transfer process of photo-excited carriers and hence delay their recombination rate can significantly increase the photocatalytic degradation of organic contaminants from the environment.Item Synthesis and in silico Analysis of 4,5-dihydro-1H-pyrazole derivative(Tashkent Institute of Chemical Technology, 2026) Mohd Akil, Iqbal Azad, Abdul Rahman Khan, Naseem AhmadThe present work reports the synthesis of novel chalcone‐derived compounds obtained via simple condensation of chalcone derivatives with phenyl hydrazine. Their design, preparation, and biological assessment are described in detail. Structural elucidation was confirmed by FTIR, 1H NMR, 13C NMR, and HRMS analyses. In‐silico ADMET profiling, carried out using AdmetLab 3.0 and SwissADME, indicated favorable pharmacokinetic and toxicity parameters, closely resembling those of reference agents Amphotericin B and Ciprofloxacin. These findings underscore the promise of chalcone scaffolds as versatile templates for antibacterial drug development.Item Sustainable Utilization of Medicinal Plants: Exploring the Antioxidant and Anticancer Potential of Polaritybased Plant Fractions(Tashkent Institute of Chemical Technology, 2026) Jamal Akhtar Ansari, Kashaf, Ayushi, Nasreen G. Ansari, Shahzadi Bano, Abdul Rahman Khan, Snober S Mir, Anam Saleem, Satyendra Kumar SinghMedicinal plants remain an important source of bioactive compounds for the development of new therapeutics. In the present study, polarity-based fractions of Ricinus communis, Baliospermum montanum, Luffa acutangula, and Coriandrum sativum were evaluated for their antioxidant and antiproliferative activities against human breast cancer cell lines (MCF-7 and MDA-MB-231) and DPPH free radical scavenging assay. Several fractions exhibited significant, dose-dependent inhibition of cancer cell growth, with ethyl acetate and chloroform fractions showing the strongest activities and DPPH free radical inhibition. Chemical profiling by GC–MS/MS and LC–MS/MS tentatively identified a broad range of bioactive metabolites, including phenolics, terpenoids, and fatty acid derivatives. The findings suggest that these medicinal plants possess promising antioxidant and anticancer potential and may serve as valuable sources for the discovery of novel plant-derived therapeutic agents.