Research Articles/ Conferences

Permanent URI for this collectionhttp://192.168.24.11:4000/handle/123456789/58

Browse

Start date: 2020Subject: search.filters.subject.Drug Discovery

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Antitubercular Potential of Bioactive Phytoconstituents from Andrographis Paniculata: Targeting DprE1 of Mycobacterium Tuberculosis
    (Zenodo, 2026) Samar Mujeeb1, Farhat Aisha Ansari
    Tuberculosis (TB) remains one of the leading infectious diseases worldwide, and the emergence of multidrug-resistant strains has intensified the need for novel therapeutic agents. Medicinal plants continue to provide structurally diverse bioactive molecules with significant drug discovery potential. Andrographis paniculata (Kalmegh) is widely recognized for its antimicrobial and immunomodulatory activities and may represent a promising source of antitubercular lead compounds.
  • Thumbnail Image
    Item
    PHARMACOLOGICAL POTENTIAL OF NATURALLY DERIVED CHALCONES
    (Tashkent Institute of Chemical Technology, 2026) Haroon Ahmad Khan, Saimah Khan
    Chalcones are naturally occurring polyphenolic compounds belonging to the flavonoid family and are widely distributed in fruits, vegetables, spices, and medicinal plants. Due to their simple chemical structure and diverse biological activities, naturally derived chalcones have attracted significant attention in pharmaceutical and medicinal research. This review aims to summarize the pharmacological potential of naturally occurring chalcones and highlight their therapeutic applications. Extensive studies have demonstrated that chalcones exhibit a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antimicrobial, antiviral, anticancer, antidiabetic, and neuroprotective effects. These activities are primarily attributed to their ability to modulate various cellular signaling pathways, inhibit enzyme activity, regulate oxidative stress, and influence inflammatory mediators. Furthermore, naturally derived chalcones have shown promising efficacy in preclinical studies against several chronic and infectious diseases, suggesting their potential as lead compounds for drug development. Recent advances in structural modification and molecular docking studies have further enhanced the understanding of their mechanism of action and pharmacological properties. Despite encouraging findings, challenges related to bioavailability, toxicity, and clinical validation remain to be addressed. Overall, naturally derived chalcones represent a valuable class of bioactive molecules with considerable therapeutic potential, warranting further investigation for the development of safe and effective pharmaceutical agents.
  • Thumbnail Image
    Item
    PYRAZOLE MOIETY AS A SOURCE OF NATURAL PRODUCTS: A REVIEW
    (Tashkent Institute of Chemical Technology, 2026) Yasmin Ara, Saimah Khan
    Pyrazole is an important nitrogen-containing heterocyclic scaffold that has attracted considerable attention in medicinal chemistry because of its diverse biological and pharmacological activities. Although naturally occurring pyrazolecontaining compounds are relatively rare, several natural products possessing pyrazole nuclei have demonstrated significant therapeutic potential. These compounds exhibit antimicrobial, anti-inflammatory, antiviral, antioxidant, and anticancer properties, making them valuable candidates for drug discovery and development. The present study reviews the occurrence of pyrazole moieties in natural products, their biological significance, structural characteristics, and pharmaceutical applications. Furthermore, the role of pyrazole-containing natural products as lead compounds for the development of novel therapeutic agents is discussed. The findings highlight the importance of naturally derived pyrazole compounds in modern medicinal chemistry and emphasize future opportunities for the discovery of new bioactive molecules.