Research Articles/ Conferences
Permanent URI for this collectionhttp://192.168.24.11:4000/handle/123456789/58
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Item Antitubercular Potential of Bioactive Phytoconstituents from Andrographis Paniculata: Targeting DprE1 of Mycobacterium Tuberculosis(Zenodo, 2026) Samar Mujeeb1, Farhat Aisha AnsariTuberculosis (TB) remains one of the leading infectious diseases worldwide, and the emergence of multidrug-resistant strains has intensified the need for novel therapeutic agents. Medicinal plants continue to provide structurally diverse bioactive molecules with significant drug discovery potential. Andrographis paniculata (Kalmegh) is widely recognized for its antimicrobial and immunomodulatory activities and may represent a promising source of antitubercular lead compounds.Item Phytochemical Innovations and their Therapeutic Role in Neurodegenerative Disorders(Zenodo, 2026) Farhat Aisha Ansari, B. Ali Modu, Samar MujeebNeurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) are progressive neurological conditions associated with cognitive decline, neuronal loss, and impaired quality of life. The increasing prevalence of these disorders and the limitations of existing therapeutic options have encouraged exploration of medicinal plants as alternative neuroprotective agents. The objective of this study is to examine current trends in medicinal plant research and evaluate their therapeutic relevance in neurodegenerative disorders. The methodology involved a narrative review and scientific evaluation of published literature focused on medicinal plants, phytochemicals, ethnopharmacological evidence, and molecular mechanisms associated with neuroprotection. Data from recent studies were analyzed to identify major bioactive compounds and their mechanisms of action. The findings indicate that medicinal plants and plant-derived compounds demonstrate significant neuroprotective activities through antioxidant, anti-inflammatory, anti-apoptotic, and signaling pathway modulation mechanisms. Bioactive constituents including flavonoids, polyphenols, alkaloids, and terpenoids have shown the ability to regulate oxidative stress, mitochondrial dysfunction, protein aggregation, and neuroinflammation. Several medicinal plants including Bacopa monnieri, Ginkgo biloba, Panax ginseng, and Centella asiatica have exhibited promising therapeutic outcomes in experimental and preclinical studies. In conclusion, medicinal plant research offers a promising direction for developing safer and multi-target therapeutic strategies for neurodegenerative disorders. Integration of traditional medicinal knowledge with modern pharmacological approaches may support future advancements in neuroprotective drug discovery.Item Behavioural Biases of Gen Z and Millennial Investors: A Review of Risk Perceptions and Decision-Making in Financial Markets(Shodh Sandarsh, 2025) Mohd Faiz Khan, Shujauddin KhanThis study provides a comprehensive analysis of the behavioural biases influencing Generation Z and Millennial investors, emphasizing their distinct risk perceptions and financial decisions in contemporary markets. In contrast to traditional investors, these generations exhibit significant digital exposure, reliance on FinTech platforms, and heightened social influence, which amplify cognitive and emotional biases. The paper highlights key biases such as overconfidence, herding, loss aversion, anchoring, confirmation bias, disposition effect, and mental accounting, examining their impact on portfolio decisions, trading frequency, and long-term investing success. The influence of social media, gamification in investment applications, and peer-based financial communities on altering risk perceptions is particularly noteworthy. Evidence suggests that while younger investors exhibit a greater propensity for adopting novel financial products and demonstrate higher risk tolerance, they remain significantly susceptible to behavioural biases that may distort rational decision-making. This research contributes to the growing body of literature on behavioural finance by synthesizing evidence regarding investment psychology across generations and offers implications for policymakers, educators, and financial institutions to formulate targeted interventions that foster informed and resilient investing behaviours among future generations.Item INNER TRANSITION ELEMENT BASED NANOMATERIALS(Zenodo, 2026) Nashra Fatima, Ekhlakh Veg, Tahmeena KhanNanomaterials based on inner transition elements, especially those made from lanthanides and actinides, have remarkable physicochemical characteristics that allow for multipurpose integration in energy, sensing, and medicinal applications. Recent research emphasizes how their distinct optical stability, narrow emission bands, and adjustable near-infrared luminescence enable enhanced sensing modalities, photothermal therapy, and deep-tissue bioimaging. Furthermore, hybrid nanostructures and metal organic frameworks based on lanthanides provide a variety of platforms for sustainable technologies, environmental monitoring, and catalysis. This review highlights some current research on inner transition element-based nanomaterials made using diverse techniques that have been used in a variety of applications.Item ZnO-BASED NANOCOMPOSITES AS EFFICIENT PHOTOCATALYSTS FOR DYE- CONTAMINATED WATER TREATMENT(Zenodo, 2026) Ekhlakh Veg, Nashra Fatima, Tahmeena KhanIndustrial wastewater containing synthetic dyes poses a major environmental and health concern because these pollutants are toxic, stable, and difficult to remove using conventional treatment methods. Among various photocatalysts, zinc oxide (ZnO) is extensively studied due to its low cost, chemical stability, non-toxic nature, and strong oxidative potential. Nevertheless, its practical application is restricted by a wide band gap and fast recombination of photo-generated charge carriers, which reduce activity under visible light. Recent progress shows that forming ZnO- based nanocomposites effectively overcomes these limitations by improving light absorption, suppressing charge recombination, and increasing reactive surface sites.Item PHARMACOLOGICAL POTENTIAL OF NATURALLY DERIVED CHALCONES(Tashkent Institute of Chemical Technology, 2026) Haroon Ahmad Khan, Saimah KhanChalcones are naturally occurring polyphenolic compounds belonging to the flavonoid family and are widely distributed in fruits, vegetables, spices, and medicinal plants. Due to their simple chemical structure and diverse biological activities, naturally derived chalcones have attracted significant attention in pharmaceutical and medicinal research. This review aims to summarize the pharmacological potential of naturally occurring chalcones and highlight their therapeutic applications. Extensive studies have demonstrated that chalcones exhibit a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antimicrobial, antiviral, anticancer, antidiabetic, and neuroprotective effects. These activities are primarily attributed to their ability to modulate various cellular signaling pathways, inhibit enzyme activity, regulate oxidative stress, and influence inflammatory mediators. Furthermore, naturally derived chalcones have shown promising efficacy in preclinical studies against several chronic and infectious diseases, suggesting their potential as lead compounds for drug development. Recent advances in structural modification and molecular docking studies have further enhanced the understanding of their mechanism of action and pharmacological properties. Despite encouraging findings, challenges related to bioavailability, toxicity, and clinical validation remain to be addressed. Overall, naturally derived chalcones represent a valuable class of bioactive molecules with considerable therapeutic potential, warranting further investigation for the development of safe and effective pharmaceutical agents.Item PYRAZOLE MOIETY AS A SOURCE OF NATURAL PRODUCTS: A REVIEW(Tashkent Institute of Chemical Technology, 2026) Yasmin Ara, Saimah KhanPyrazole is an important nitrogen-containing heterocyclic scaffold that has attracted considerable attention in medicinal chemistry because of its diverse biological and pharmacological activities. Although naturally occurring pyrazolecontaining compounds are relatively rare, several natural products possessing pyrazole nuclei have demonstrated significant therapeutic potential. These compounds exhibit antimicrobial, anti-inflammatory, antiviral, antioxidant, and anticancer properties, making them valuable candidates for drug discovery and development. The present study reviews the occurrence of pyrazole moieties in natural products, their biological significance, structural characteristics, and pharmaceutical applications. Furthermore, the role of pyrazole-containing natural products as lead compounds for the development of novel therapeutic agents is discussed. The findings highlight the importance of naturally derived pyrazole compounds in modern medicinal chemistry and emphasize future opportunities for the discovery of new bioactive molecules.Item GREEN SYNTHESIS OF PYRAZOLE(Tashkent Institute of Chemical Technology, 2026) Sayyeda Rushan, Saimah KhanHeterocyclic rings named pyrazole-containing compounds show a significant role in medicinal chemistry, owing to various FDA-approved drugs that are used in the treatment of carcinomas as well. Such a five-membered ring has different conformations through their active sites that interact with the targeted amino acid residues and consequently show good inhibition against targeted proteins. Green chemistry is an interdisciplinary field that focuses on minimizing hazardous substances and promoting sustainable alternatives in chemical processes to conventional chemical processes and products. This review provides a comprehensive analysis of the fundamental principles, historical development, and practical applications of green chemistry with a particular emphasis on its role in advancing sustainable chemical synthesis, analytical methodologies, and industrial practices. Chemists availed synthesis to the discovery of drugs using a chemically reaction-based strategy. For that, the analytical techniques named FT-IR, 1H NMR and 13C NMR spectroscopic were applied to the molecular structure’s evaluation. Not only that, but ESI-MS/HRMS spectrometry tools have an important role for the confirmation of synthesized compounds. The various methods for drug discovery are used, like in silico, in vitro and in vivo analyses, to find their biological effects against the targeted proteins. The aim of this research is the discovery of pyrazole-containing drugs that could be used in the treatment of various carcinomas.Item NUTRIENT REMOVAL FROM SYNTHETIC WASTEWATER CONTAINING CIPROFLOXACIN AND AMOXICILLIN USING HORIZONTAL FLOW CONSTRUCTED WETLAND(Liberty Publishing House, 2025) Zeba Ali Mumtaj, Zainab Feroz, Saimah KhanThe removal efficiency of ciprofloxacin and amoxicillin in wastewater treatment can be significantly influenced by monthly variations (January-February & March-April) and the presence of vegetation. CWs are one such alternative that can efficiently remove variety of pollutants from wastewater. Constructed Wetland (CWs) is viewed as a low-cost treatment technology with proven treatment efficiency. CWs can treat a variety of contaminants using low energy and natural systems by altering various design parameters. In this study two horizontal flow constructed wetlands (HFCW) are used and the concentration of antibiotics namely ciprofloxacin and amoxicillin, in each synthetic wastewater is 50ppm. The parameters were studied for influent and effluent wastewater. This study reports comparative pollutants removal from synthetic wastewater using HFCW. The water samples were collected as grab samples after 24 hours of duration. Results showed that CWs with reeds shows higher removal efficiency than without reed CWs considering nitrate and phosphate. From the results, it was also concluded that the removal efficiency of nitrate (49-89%) and removal efficiency (%RE) of phosphate ranges between (39-96%) in planted and non-planted CW.Item VIBRANIUM: SCIENTIFIC INVESTIGATIONS AND COMPARATIVE ANALYSIS OF POSSIBLE APPLICATIONS AND REAL-LIFE RESEMBLANCE(Liberty Publishing House, 2026) Mohd Arsh Khan, Wazeeha Zubair Ansari, Zeba Ali Mumtaj, Naseem Ahmad, Saimah KhanVibranium is a fictional metal from the Marvel Universe which has sparked scientific interest because of its incredible hypothetical properties. This paper offers a scientific concept analysis of Vibranium by studying its assumed physical chemical mechanical and electronic properties and comparing them with extraordinary materials existing in reality. The metal is speculated to have an amazing strength-to-weight ratio, high thermal and electrical conductivity, outstanding resistance to corrosion and the capability to absorb and dissipate energy. Such features are indicative of possible uses in aerospace engineering, advanced electronics, biomedical implants, energy storage systems, high-temperature industrial components and defence. Besides proposing possible routes of synthesis, methods of theoretical modelling and techniques of characterization which might be applied to explore such materials if they existed. We also discussed the resemblances between Vibranium and present-day high-quality materials like tungsten, titanium alloys and carbon-fibres composites to add a scientific perspective. This idea of using fictional materials can lead to innovative thinking in materials science and can also serve as a source of inspiration for the development of multifunctional high, performance materials for future technological applications.