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Permanent URI for this collectionhttp://192.168.24.11:4000/handle/123456789/237

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Author: search.filters.author.Rufaida WasimSubject: search.filters.subject.PHARMACY

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    Therapeutic Impact of Exosomes in Stroke and Transient Ischemic Attack
    (Springer, Singapore, 2024) Rufaida Wasim; Anas Islam, Asad Ahmad, Aditya Singh, Azhar Mahmood Farooqui ,Yusuf Asad
    Stroke and transient ischemic attack (TIA) are debilitating neurological conditions characterized by a sudden disruption of blood flow to the brain, resulting in tissue damage and functional impairments. Despite extensive research efforts, effective therapeutic interventions for stroke and TIA remain limited. However, recent advancements in the field of exosome-based therapeutics have shown promising potential for the treatment of these brain disorders. Exosomes, small extracellular vesicles secreted by various cell types, have emerged as key mediators of intercellular communication, owing to their ability to transport bioactive molecules and modulate cellular functions. This chapter discusses the therapeutic effects of exosomes in stroke and TIA, elucidating the mechanisms underlying exosome-mediated neuroprotection. Furthermore, the chapter delves into the challenges associated with exosome-based therapies, including limitations and barriers to clinical translation. Strategies to overcome these challenges are discussed, along with emerging trends and future directions in exosome research for stroke and TIA. In conclusion, this chapter highlights the therapeutic impact of exosomes in stroke and TIA, underscoring their potential as a novel and promising avenue for therapeutic intervention. By addressing the current knowledge gaps and exploring future research directions, this chapter aims to contribute to the advancement of exosome-based therapies in clinical practice.
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    Epigenetics as Diagnostic and Therapeutic Tool in Neurodegenerative Disorders
    (Bentham Science, 2024) Rufaida Wasim; Tarique Mahmood, Farogh Ahsan, Aditya Singh, Asad Ahmad
    Epigenetics is a field that is concerned with the investigation of heritable modifications in gene expression that transpire without DNA sequence alterations, thereby establishing a connection between the genome and its surroundings. Epigenetics simply analyzes gene expression amendment beyond variation to the DNA sequence. The gradual accumulation of epigenetic changes over the course of an individual's life span may contribute to neurodegeneration. This chapter deals with epigenetic alteration, which affects the progress of neurodegeneration with age. Epigenetic regulation, encompassing DNA methylation and histone modification, has been implicated in the anomalous alterations in gene expression that occur during the progression of neurodegeneration. The concept of epigenetics is useful to synthesize novel medications to target these disorders. In recent times, a plethora of epigeneticsbased medications have been developed for the treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Due to a major lack of early screening processes that allow therapeutic agents to be distributed to afflicted neurons paramount to cell death, many neurological conditions have severely restricted options for treatment. Significant progress has been seen in neurodegenerative disease biomarkers. These biomarkers have been unfortunate, due to substantial disparities amidst the tissues acclimated to source biomarkers and biomarkers of disease. Neurodegeneration may be exacerbated by epigenetic changes that develop gradually. Epigenetic biomarkers could aid in the diagnosis, and monitoring, of neurodegenerative diseases.