Books/Book Chapters/Edited Books

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Start date: 2022Subject: search.filters.subject.PHARMACY

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    Gut Microbiota and Colorectal Cancer Pathogenesis
    (Humana, Cham, 2025) Anas Islam, Badruddeen, Mohammad Irfan Khan, Mohsin Vahid Khan, Yusuf Asad
    This chapter explores the complex relationship between the gut microbiota and the pathogenesis of colorectal cancer (CRC), highlighting the role of microbial dysbiosis in promoting inflammation, DNA damage, and immune dysregulation. It reviews key pro-carcinogenic bacteria, such as Fusobacterium nucleatum, Bacteroides fragilis, and pks+ Escherichia coli, which contribute to tumor initiation and progression. The chapter also discusses the protective effects of beneficial microbes like Lactobacillus and Bifidobacterium, which help maintain gut health and inhibit carcinogenesis. Therapeutic strategies aimed at modulating the gut microbiota, including dietary interventions, probiotics, prebiotics, fecal microbiota transplantation (FMT), and postbiotics, are examined for their potential in CRC prevention and treatment. Finally, future directions in personalized microbiome-based therapies, diagnostic biomarkers, and the challenges facing clinical translation of gut microbiota research are addressed. The chapter emphasizes the growing importance of targeting the microbiome in CRC management to enhance prevention, diagnosis, and therapeutic outcomes.
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    Antimicrobial Resistance: An Unknown Threat to Humankind
    (Integrated Publications, 2024) Sahil Hussain, Arun Kumar, Kuldeep Singh, Shom Prakash Kushwaha, Mohd. Mursal, Mohd. Shainoor
    With resistance found to every antibiotic now in clinical use and only a handful of innovative treatments in the development, antibiotic resistance is a worldwide health disaster. Understanding the molecular mechanisms that bacteria use to withstand the effects of antimicrobials is essential for identifying global patterns of resistance, optimising the use of existing medications, designing new medications that are less likely to develop resistance, and developing cutting-edge methods to combat resistance. In this review, we look at recent developments in our knowledge of how resistance genes affect the biology of the host, as well as new structural information on important molecular processes that underlie resistance, various mechanism of resistance and method of destruction of antibiotic through variety of different enzymatic action and other methods involved such as efflux and conformational changes that are adopted by the bacteria and other microorganism to combat antibiotics. Finally, we go over how we can apply this knowledge to create the newest antimicrobial treatments.
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    Innovations in Pharmaceutical Technology: Transforming Drug Discovery and Development
    (M/S Academic Publishers & Distributors, Lucknow, India, 2025) Pradip Kumar, Pankaj Bhatt, Monowar Alam Khalid, Juber Akhtar, Ravikant Singh
    The field of pharmaceutical technology is advancing rapidly, with groundbreaking innovations in drug discovery and development transforming modern medical sciences. These advancements are not only revolutionizing treatment methodologies but also driving the development of more precise, effective, and personalized therapeutic solutions. This book, Innovations in Pharmaceutical Technology: Transforming Drug Discovery and Development, serves as a comprehensive reference, compiling cutting-edge research and emerging trends that are shaping pharmaceutical and biomedical sciences. With twelve meticulously curated chapters, this volume explores advanced pharmaceutical technologies, bridging the gap between traditional approaches and modern scientific breakthroughs. Key areas covered include 3D Printing, Quantum computing, Drug testing, drug discovery and development, microbiome targeted therapies, AI and ML in drug designs and stem cell and tissue engineering. We are deeply grateful to the renowned researchers and scholars whose contributions have enriched this volume. Their expertise has made this book a valuable resource for academics, researchers, and industry professionals. We extend our sincere appreciation to our colleagues and university authorities for their unwavering support and encouragement. Lastly, we express our heartfelt gratitude to our families and friends for their patience, motivation, and support throughout this endeavour. We hope this book serves as an inspiration and valuable guide for researchers, scholars, and practitioners, fostering future innovations in drug discovery, development, and pharmaceutical technology.
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    Quality assurance framework for smart drug delivery systems in pharmaceutical industries and its applications
    (CRC Press, 2024) Sara Khan, Juber Akhtar, Muhammad Farhan, Nortoji A. Khujamshukurov, Badruddeen, Mohammad Irfan Khan, Mohammad Ahmad, Zainab Fatima
    Quality assurance is a key term used in manufacturing industries to ensure the safety, efficacy, stability, reliability, potency, purity, and quality of the products that are delivered to the customers. It ensures that the final product is physically, chemically, and biologically fit for the purpose for which it is developed. Quality assurance framework is basically a method to monitor the quality of a process or the product throughout the process i.e., from the selection of raw material till the production of the required product/drug and prevent mistakes and defects during production and development. Smart systems refer to novel systems or approaches to design and deliver desired drugs/products with minimum side effects, maximum therapeutic potency, and improved patient compliance/acceptability. Hence, the quality-assured framework in smart systems is intended to assure that established quality standards of the final product are met when novel approaches are employed in the development/production of drug delivery systems.
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    Management of Gut MicrobiotaDerived Bacterial Metabolites Induced Inflammatory Bowel Disease
    (Apple Academic Press, 2025) Monika Vishwakarma, Poornima Agarwal, Faheem Haider, Tanweer Haider, Vandana Soni
    Inflammatory bowel disease (IBD) is the most common issue in every generation of individuals due to their eating habits, stress, and unhealthy lifestyle. IBD occurs due to chronic inflammation of digestive tract tissues, mainly characterized by symptoms such as diarrhea, abdominal cramps, blood in stool, etc. Ulcerative colitis and Crohn’s disease are the two variants of IBD that affect the linings of the large intestine, rectum, and gastrointestinal tracts. The human gastrointestinal tract contains trillions of good and bad microorganisms such as bacteria, fungi, viruses, and many others that form gut microbiota. These microorganisms use dietary substances to form metabolites that maintain a healthy gut environment. Excessive use of antibiotics and a high intake of a westernized diet have led to the degradation of good gut bacteria and an increase in the count of bad bacteria, which release harmful metabolites such as bile acids, short-chain fatty acids, tryptophan metabolites, and sphingolipids. These metabolites induce several diseases, of which IBD is one. Prebiotics, probiotics, and fecal microbiota transplantation are employed for treating bacterial-induced IBD. In this chapter, we will discuss the bacterial metabolites that induce IBD and its treatment strategy.
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    Smart Nanomaterials in Drug Delivery for Cancer Therapy
    (Springer, Singapore, 2025) Asim Rahman, Nazish Naseem, Amreen Fatima, Md. Faheem Haider
    In today’s world, one of the leading diseases people are facing is cancer, and liver cancer is one of them. Though various drugs acting via different mechanisms of action are present in the market as conventional formulations for the treatment of liver cancer they face substantial challenges regarding their bioavailability, low solubility and associated adverse effects which greatly limit their therapeutic efficacies. Nanotechnology has emerged as a promising tool for cancer therapy. Smart nanomaterials, in particular, have gained significant attention due to their unique properties, such as high surface area, biocompatibility, and the ability to be functionalized with targeting moieties. Smart nanomaterials can be designed to selectively deliver drugs to cancer cells, improve drug efficacy, and reduce toxicity. Various studies exhibit that nanocarriers can significantly increase drug bioavailability and increase solubility. The present chapter summarizes nanoformulations used in the treatment of liver cancer. It also highlights the available therapeutics in the market which is used for the treatment of liver cancer along with their side effects and drawbacks and how nanoformulation can overcome these drawbacks of present therapeutics.
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    Pulmonary drug delivery of lipid-based formulations via nebulizers
    (Elsevier Inc., 2025) Anas Islam, Ambareen Fatima Ahmed, Widhilika Singh, , Usama Ahmad, Asad Ahmad, Mohd Muazzam Khan, Md Faiyazuddin
    Nebulizers are medical equipment that transform liquid drugs into inhaled aerosols. They are widely utilized in the management of respiratory conditions such cystic fibrosis, asthma, and chronic obstructive pulmonary disease (COPD). Compared with alternative pulmonary drug delivery methods, lipid-based nebulizers have several benefits, such as the capacity to encapsulate medications and shield them from deterioration, as well as their safety and biocompatibility profiles. The goal is to emphasize the potential of lipid-based nebulizers as a viable drug delivery technology for the treatment of respiratory disorders and to explain the benefits of employing lipid-based formulations for pulmonary medication delivery. The chapter discusses the several types of nebulizers and their applications, as well as formulation development, nebulizer performance, and clinical applications. The importance of this chapter stems from its ability to aid researchers and physicians in the development and deployment of lipid-based nebulizers for pulmonary medication delivery, resulting in enhanced treatment choices for patients with respiratory disorders.
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    Mechanisms of Antimicrobial Drug Resistance
    (Nova Science Publishers, Inc., 2024) Arun Kumar , Mohd. Mursal, Sahil Hussain, Kuldeep Singh, Sana Ahmad, Deepshikha Singh, Kaynat Fatima
    Antimicrobial resistance occurs through enzyme-driven drug breakdown, bacterial protein modifications, and alterations in antibiotic permeability, and can be transmitted through plasmids or ingrained within the bacterial chromosome. The primary mechanism responsible for resistance to cephalosporins and penicillin is the enzymatic hydrolysis of these antibiotics by the bacterial enzyme β-lactamase. The presence of chromosomal β- lactamase can be influenced by exposure to β-lactam drugs, leading to either induced expression or sustained inhibition. Strategies to counteract resistance to β-lactam antibiotics involve two main approaches: first, the development of novel antibiotics that are resistant to β-lactamase degradation; and second, the concurrent use of β-lactamase inhibitors alongside β-lactam drugs. Methicillin resistance, which remains unaffected by gram-positive β-lactamase, arises due to modifications in penicillin-binding protein. The main mechanisms of resistance for other classes of antibiotics, encompassing trimethoprim, sulphonamides, aminoglycosides, chloramphenicol and quinolones, involve two key processes: the creation of enzymes that modify the antibiotics, and the development of bacterial targets that are resistant to the effects of these antibiotics. For several antibiotic families, including quinolones, aminoglycosides, β-lactams and chloramphenicol, decreased antibiotic penetration acts as an additional resistance mechanism.
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    Liposomes: History, Properties, and Applications
    (Nova Science Publishers, Inc, 2024) Shivangi Sharma, Anas Islam, Mohd Muazzam Khan, Usama Ahmad
    The use of liposomes in nanotechnology has become more widespread in recent years. Liposomes are self-assembled particles having a water chamber that is surrounded by a lipid bilayer. This chapter has covered the liposomes in great detail, including how and where they were created, a broad description of their structure, and what distinct types of lipids they are composed of. Depending on their size, liposomes can be classified into several distinct varieties, such as enormous liposomes, multilamellar liposomes, and unilamellar liposomes. Depending on the context, different liposomes can be produced using various preparation techniques. In this chapter, we have also learned about the several fields in which liposomes have been extensively employed for the treatment of various diseases, biotechnology research, cosmetic items, nutraceuticals, and food. To increase the stability of the core, liposomes are important in the encapsulation of a variety of bioactive compounds (BACs), including functional food additives. In this chapter, we have also discussed the future perspective and scope where liposome technology can be exploited, the different fields in which liposome nanotechnology can be a boon, and the revolution it can make in pharmaceuticals.
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    Exploring the Potential of Marine Drugs: A Patent Perspective
    (Apple Academic Press, 2025) Anas Islam, Usama Ahmad, Md Faiyazuddin, Asad Ali, Mohd. Muazzam Khan
    The ocean is a potential source of bioactive compounds, but unlike terrestrial plants, it does not have a long history of use in traditional medicine. The marine environment is a one-of-a-kind resource with vast biological diversity that, if properly explored, could lead to breakthrough therapies. The influence of this sector on the pharmaceutical industry is growing as more substances derived from marine sources enter clinical testing. Marine creatures contain a large number of naturally occurring compounds with various structural and pharmacological properties. The recent rise in patent publications amply supports the importance of these compounds as sources of novel therapeutic agents. Marine-derived actives are being researched as prospective sources for anti-cancer, anti-bacterial, antiviral, and anti-inflammatory medications, as well as treatments for a range of other conditions, despite critical supply limitations. As the number of lead marine compounds increases, it becomes essential to explore the ongoing status of patents filed and granted in the field of marine pharmaceuticals. In this chapter, an effort has been made to gather valuable information on the recent patents available on various marine drugs.