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    Metallic Nanocarriers in the Delivery of Phytomedicines
    (Cambridge Scholars Publishing, 2023) Tarique Mahmood Ansari; Laxmi Devi, Poonam Kushwaha, Ashish Kumar
    Phytomedicines derived from plants have a wide range of pharmacological applications in a variety of diseases. One of the most important advantages of phytoconstituents is their low toxicity and adverse effects. However, their therapeutic efficacy is hampered by low solubility, permeability, and specificity in the target region. As a result, novel drug delivery systems are being developed employing a variety of nanoformulation methodologies to overcome these limitations and provide consistent drug delivery at the targeting location in the optimal concentration as well as increased therapeutic efficacy. Novel drug delivery systems are one example of such approaches (NDDS). In comparison to alternative options, using herbal formulations for NDDS is more advantageous. The utilization of inorganic nanoparticles of plant extract is an important idea for the herbal formulations. These are used to achieve the targeted administration of the formulation, which influences the location and enhances its bioavailability. The constituents and extracts used in natural formulations demonstrate sustained release, enhanced stability, increased therapeutic efficacy, and toxicity prevention due to such novel drug delivery systems. The fundamental motivation for developing alternative drug delivery systems is
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    Targeted Drug Delivery to Combat Antibacterial Drug Resistance
    (IGI Global, 2024) Kuldeep Singh; Nitin Pandey,Shom Prakash Kushwaha, Arun Kumar, Mohammad Khalid, Ahsan Ahmed Khan, Maaz Khan
    In targeted drug delivery, antibiotics are precisely delivered to infection areas using nanoparticles and carrier systems, increasing effectiveness, lowering side effects, and causing the least amount of damage to the microbiota. By increasing local antibiotic concentrations, releasing antibiotics selectively depending on bacterial indicators, and using synergistic combination treatments, this approach combats antibacterial resistance. Diagnostics, real-time monitoring, and responsive medication delivery are all combined on multifunctional platforms made possible by nanotechnology. Though problems like biocompatibility and regulatory barriers still exist, recent research has shown promise both in vitro and in vivo. Targeted drug delivery, subject to additional study and invention, offers a method to increase antibiotic effectiveness while tackling resistance. It promises to improve the management of infectious diseases. Targeted distribution can address a variety of problems related to antibacterial resistance.
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    Nanotechnology in Phytopharmaceuticals
    (Cambridge Scholars Publishing, 2023) Tarique Mahmood; Arshiya Shamim, Mohammed Haris Siddiqui, Farogh Ahsan
    In recent times, nanotechnology has emerged as a powerful tool in the field of pharmaceutical sciences. Herbal nanoformulations have drawn a lot of attention for their extensive application, reduced dose and enhanced efficacy. Herbal nanoparticles are loaded with either plant extract or plant active isolate, set a higher benchmark than their modern counterparts, and hold an almost equivalent pharmacological potential with lower side effects, making them a lucrative option. This work is a detailed review of plantbased nanoparticles as an advanced therapeutic vehicle for the delivery of various herbal actives. It further elaborates different categories of nanoparticles such as polymeric nanoparticles, metallic nanoparticles, etc., along with their methods of preparation namely the hot homogenization method, co-precipitation method, cold homogenization method, salting out method, ionic gelation method, etc., including various characterization techniques such as ultraviolet spectroscopy, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, x-ray diffraction, zeta potential, etc. These are applied for exploring the size, size distribution, surface charge shape, density, nature, magnetic properties and surface area and this is mandatory for the successful development of herbal nanoparticles. This chapter also discusses the different in-vitro and in-vivo characterizations of nanoparticles that have been done so far to establish them as a novel formulation in pre-clinical and clinical studies. Hence, from this extensive compilation, it can be clearly understood that the implementation of nanotechnology in the herbal drug delivery system can enhance the efficacy of herbal drugs.
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    Nanomaterials from Agricultural and Horticultural Products
    (Springer Nature, 2024) Husen, Azamal ed.; Jawaid, Mohammad ed.
    Nanotechnology is the state-of-the-art technology providing new horizons of ideas and scope to unlimited possibilities in almost all genres of day-today life ranging from diagnostic, therapeutic, agricultural, chemical to microelectronics, sensors, etc. In this connection, one of the main concerns regarding the metal-oxide nanoparticles is their synthesis, application in a safe mood to protect the overall toxic impact on the food web. To resolve this concern, a greener and cleaner method of producing the nanoparticles is being looked upon as a favorable alternative more commonly referred to as green chemistry or green synthesis. The metal-oxide nanoparticles synthesized from biological sources have demonstrated fulfilling properties and shown antibacterial, antiviral, antifungal, drug delivery, catalytic activity, etc., response. In this chapter, the role of fruits and their wastes in the green synthesis of metal-oxide nanoparticles is discussed. This could efficiently reduce the cost and is safer for the environment thus allowing us to implore more on their benefits without impending much harm to the environment.