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Subject: search.filters.subject.Oxidative stress

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    Jasmonic Acid-Mediated Defense in Vicia faba: Alleviating Fungicide-Induced Oxidative Stress
    (Book Rivers, 2026) Aneeta Tiwari, Ashish Verma
    Plants are constantly subjected to various environmental stressors that significantly impede their growth and limit agricultural productivity. These stressors are classified as abiotic (such as extreme temperatures, drought, salinity, radiation, and heavy metals) and biotic (including fungi, bacteria, viruses, nematodes, and herbivores). To counter these challenges, plants have developed sophisticated defense mechanisms that involve sensing stress signals, activating signaling cascades, and initiating cellular responses. In agricultural settings, plants frequently face combined stress conditions, intensifying damage and reducing yields. Among the most damaging biotic agents are fungi and oomycetes, which are responsible for substantial global crop losses. The faba bean (Vicia faba L.), a widely cultivated legume, is highly susceptible to various fungal diseases such as rust, chocolate spot, ascochyta blight, leaf spots, and root rot complexes, often resulting in severe defoliation and yield decline. Disease management traditionally involves resistant crop varieties, improved cultural practices, and the extensive use of fungicides like mancozeb. While fungicides such as mancozeb effectively suppress pathogens, their overuse leads to oxidative stress due to the accumulation of reactive oxygen species (ROS), which disrupt cellular homeostasis. Plants mitigate oxidative damage through robust antioxidant systems comprising enzymatic (SOD, CAT, POD) and non-enzymatic (ascorbate, glutathione, carotenoids) components. Plant growth regulators (PGRs), particularly jasmonic acid (JA), have emerged as critical tools in enhancing plant resilience by strengthening antioxidant defenses and regulating stress responses. JA modulates stress adaptation by interacting with other phytohormones and regulating key physiological processes, thereby offering a promising, eco-friendly strategy to reduce the adverse impacts of both environmental stress and chemical treatments.
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    Antimicrobial, Antioxidant and Anticancer Potential of Andrographis Paniculata: Phytochemical Insights and Biomedical Implications
    (Book Rivers, 2026) Hina Khatoon, Mohammad Haneef, Salman Akhtar
    Oxidative stress and cancer continue to pose major challenges to global health, contributing significantly to illness and death worldwide. Growing concerns over the adverse effects of synthetic drugs have intensified interest in natural, plant-based remedies. This chapter presents an in-depth overview of the antioxidant and anticancer potential of Andrographis paniculata, commonly referred to as the "King of Bitters." It delves into the biochemical basis of oxidative stress, the therapeutic relevance of antioxidants, and the crucial role of natural compounds in cancer prevention and therapy. Additionally, the chapter discusses the phytochemical constituents, traditional applications, and pharmacological benefits of A. paniculata, particularly its anti-inflammatory, hepatoprotective, antidiarrheal, and anticancer effects. Emphasis is placed on the need for further targeted research to substantiate its clinical effectiveness and safety, underscoring its promise in the development of innovative therapeutic agents.
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    Natural Compounds and Oxidative Stress Management
    (Springer, Singapore, 2025) Ruchi Yadav, Namira Sana, Uzma Afaq, Chand Bibi, Jahanarah Khatoon
    Natural compounds and their bioactive derivatives are rich sources of antioxidants, including flavonoids, anthocyanin, polyphenols, lignans, carotenoids, and vitamins. Antioxidants can manage oxidative stress-related infections and chronic inflammation by boosting the immune system. A resilient immune system will neutralize harmful free radicals in our body and reduce their levels. The trigger factor for production of oxidative stress is an imbalanced state between free radical formations to available antioxidants present in the body. Natural plant extracts exhibit multi-therapeutic effects by modulating diverse biochemical pathways. Additionally, the lower toxicity associated with natural products and their secondary metabolites reduces the risk of side effects. Antioxidants can regulate both stress-induced signaling pathways and oxidative defensive pathways. Secondary metabolites extracted from natural compounds exhibit both antioxidant and anti-inflammatory activities. Antioxidants’ ability to scavenge reactive oxygen species (ROS) makes them promising candidates for treating several illnesses, such as neurodegenerative diseases, diabetes, and cancer. This book chapter highlights the therapeutic effects ingrained in natural sources of antioxidants and tries to shed light on exploring the exact mechanism behind the therapeutic effects.
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    Oxidative Stress and Antioxidant Mechanism
    (The Pustakalaya, 2025) Mubeen, Pratiksha, Nadeem Khan, Abhishek Kumar