Faculty Publications

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Scholarly Publications by Integral Academia

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Liposomes - Recent Advances, New Perspectives and Applications
(IntechOpen, 2023) Abdul Hafeez; Usmani, Shazia Afzal; Tyagi, Rajiv K. ed.
The Metabolic role of Peroxisome in health and disease
(IntechOpen, 2022) Usmani, Shazia Afzal; Shadma Wahab; Abdul Hafeez; Khatoon, Shabana; Syed Misbahul Hasan; Hasan Basri Ila ed.
Perspective Chapter: Nose-to-Brain Drug Delivery through Liposomes - Recent Applications
(IntechOpen, 2023) Abdul Hafeez; Shazia Afzal Usmani
Diseases related to the brain are causing a huge problem worldwide. Different drug formulations are available for the management of brain-related disorders, but due to less drug availability for the brain and non-specificity, it becomes difficult to completely cure life-threatening brain disorders. The blood-brain barrier (BBB) restricts the entry of drug molecules/drug-loaded carriers because of the presence of various efflux transporters and drug inactivating enzymes. Researchers have identified an intranasal route for direct delivery to the brain, bypassing BBB. Nanotechnology-enabled lipid-based drug carrier systems have shown potential for the management of brain diseases through nose-to-brain delivery. Liposomes are the most extensively investigated carrier systems because of biocompatibility, controlled release characteristics, easy surface modification, and biodegradability. This chapter highlights the important aspects of nose-to-brain delivery and strategies for enhancing the availability of drugs through liposomes in the management of different brain-related diseases.