The Indian Knowledge System (IKS) represents a vast and diverse repository of ancient wisdom, philosophies, practices, and systems of learning that span across multiple disciplines, including science, mathematics, philosophy, literature, medicine, art, and spirituality. Rooted in the country's rich cultural heritage, IKS is characterized by an integrated and holistic approach to understanding the universe, human existence, and its interconnections. This chapter delves into how IKS has impacted each discipline, and understanding IKS is a must for in-depth understanding.