Faculty Publications
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Scholarly Publications by Integral Academia
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Item The Impact of Air Pollution and Environmental Factors on COVID-19 Transmission(2023) Tahmeena Khan; Alfred J. Lawrence , Vinay P. AnejaSARS-CoV-2 (COVID-19) has caused serious mortal damage to the human race. The virus causes respiratory infections, and many studies are trying to comprehend the mode of spread and infection. This chapter has explained the origin of the virus, its structure and activity domain, symptoms, medicinal interventions, and particularly various modes of spread with emphasis on air pollution as contributing and facilitating factors assisted with favourable meteorological conditions, including temperature and relative humidity. Pieces of evidence from different countries suggest that the spread of the virus may be facilitated by air pollution and people who are exposed to high pollution levels are more susceptible to falling victim to the virus. Transmission of the SARS-CoV-2 may be facilitated by the airborne particulate matter, and both particulate matter and coronavirus cause oxidative stress in the body that helps in enhancing the susceptibility and severity towards respiratory infection. Not only ambient air pollution, but indoor air pollution (IAP) is also a factor worth considering. People in developing and under-developed nations are at high risk as they are exposed to high IAP levels. Awareness must be created to educate them about the associated harmful consequences, including the risk of catching the lethal COVID-19 infection. In the absence of any concrete medicinal solution, it is necessary to build immunity which may be uplifted by the usage of natural food sources, including herbs and spices. An overview of some commonly available herbs and spices of medicinal importance has also been given in the chapter.Item Vaccination Hesitancy and Adaptation with Particular Emphasis on Women(Bentham Science, 2023) Tahmeena KhanThe novel beta-coronavirus SARS-CoV-2 (COVID-19) emerged in 2019 in Wuhan from bats and later caused inter-human transmission. India is one of the worst- hit countries, where two million casualties have taken place during the second wave of the pandemic. The year 2021 witnessed the more deadly form of the virus. At the same time, there was remarkable progress in vaccine development resulting in the approval of a few vaccines by the governments. The process of COVID-19 vaccination has kickstarted in many countries. The general attitude towards acceptance of the vaccine has been reported in countries like the USA and Jordan. Very few studies have reported the understanding and hesitation regarding the vaccination among the Indian population, and the present study is an attempt to highlight the general mindset, acceptance, misconceptions and awareness regarding the COVID-19 vaccination from the Indian perspective. Being one of the worst-hit countries in terms of COVID-19, it is important to identify the barriers holding the Indian population back from getting vaccinated. This study was done as a questionnaire survey aimed at knowing the general apprehension, and thoughts of the public regarding the vaccination with 308 respondents, precisely of Indian origin. 58.8% (n=181) respondents were non- vaccinated. 45.2% (n=95) respondents reported that their respective employers made vaccination compulsory. 51.5% (n=120) felt that the vaccine is 60-80% safe. The results may be used by the public health authorities to identify the priority group and the barriers holding people back from vaccination.Item Biomedical Applications of 1D and 2D Carbon-Based Nanomaterials(springer, 2024) Tahmeena Khan; Saman Raza, Qazi Inamur RahmanBiomedical applications of nanomaterials have gained attention because of their pivotal role in the improvement of human health. As compared to bulk mate- rial, nanomaterials have improved diagnostic and therapeutic applications. Carbon- based nanomaterials have remarkable potential for biomedical applications like biosensing, drug delivery, and gene therapy. Carbon-based one-dimensional (1D) and two-dimensional (2D) materials have excellent thermal, mechanical, and optical properties and possess structural diversity. Carbon has several interesting allotropes, like carbon nanotubes (CNTs), graphene oxide (GO), and graphene quantum dots (GDQs). These allotropes have been associated with numerous biological applica- tions like biosensing and drug delivery. This chapter explores the biomedical applica- tions of 1D and 2D carbon-based nanomaterials, including CNTs, graphene, GO, and reduced graphene oxide (RGO). The structural features and their specific applications in the biomedical field have been elaborated, taking examples from the literature. Potential toxicity risks on living organisms and the environment are also discussed, along with their applications. It is pertinent to comprehend their interaction with living systems to use them for biomedical applications.Item COVID-19: Origin, Impact and Management (Part 1)(Bentham Science Publishers, 2023) Tahmeena KhanItem From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’ for breast Cancer(Jupiter Publication, 2023) Mohammad Imran Ahmad; Tahmeena KhanBreast cancer is still the leading cause of cancer deaths among women worldwide. According to the Global Cancer Observatory (GLOBOCAN) reports, there were more than 19 million cancer cases worldwide for the year 2020[1]. India ranked third after China and the United States of America. According to GLOBOCAN prediction the cancer cases in India would increase to approximately more than 2 million, that is, increase of more than 57 per cent in 2040 from 2020[2]. For treatment of breast cancer new therapies and drugs are continuously being conceived and explored. Recent results from literature search have suggested the benefits of indole based compounds for the prevention of many types of cancer, including breast cancer. Among the most efficacious drugs for treatment of breast cancer are indole based therapeutics such as structurally complex antimitotic vinca alkaloids, and the synthetic receptor tyrosine kinase inhibitor sunitinib. Indole based molecules show their anti-breast cancer activity through various mechanistic pathway (Fig. 1). This review will ellaborate an insight into the latest developments in the field of indole based drugs against breast cancers with a special emphasis onindole containing natural products, semi-synthetic and synthetic molecules and their targets and modes of action.Item BASICS OF FOOD CHEMISTRY(Book Rivers, 2024) Ekhlakh Veg; Mohammad Imran Ahmad; Tahmeena KhanItem Computational Toxicology Studies of Chemical Compounds Released from Firecrackers(Bentham Science Publisher, 2023) Tahmeena Khan; Alfred J. Lawrence, Nikita TiwariItem Computational Toxicology for Drug Safety and a sustainable Environment(Bentham Science Publisher, 2023) Tahmeena Khan; Saman RazaItem Need of Technological Interventions for Indoor Air Quality and Risk Assessment Upon Short-Term Exposure: A Futuristic Approach(Springer, 2023) Tahmeena KhanThis chapter is intended to elaborate the health hazards linked to short-term rise in pollutants, which often goes unnoticed but has a critical impact and how with the help of IoT-based applications, the short-term variation can be predicted through different strategies. Similarly, the assessment of the health impact associated with short-term exposure to air pollution is also significant, and different exposure assessment models and computational strategies are discussed in the course of the study.