Faculty Publications
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Scholarly Publications by Integral Academia
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Item Recent progress in CAR-T cell therapy for B-cell cancers with resistant tissues(Academic Press, 2026) Rajesh Kumar , Seetha Harilal , Mohd Aftab Siddiqui , Mohhammad Ramzan , Sumel AshiqueThe therapy of B-cell cancers, particularly lymphomas, has undergone a tremendous change with the approval of chimeric antigen receptor (CAR)-T cell therapy, and is currently widely available, which can be considered as a standard therapeutic option, in the case of patients having aggressive lymphomas, even though being utilized after multiple lines of treatment. The current CAR-T cell therapies, which are approved by the FDA works by targeting the antigens such as CD19 or BCMA present in the B cells. The CAR-T cell therapies are rapidly advancing with new findings to address the current limitations, including toxicities, and resistance; such as targeting multiple antigens, the source and the delivery of genetic material into the T cells, utilization of nanotechnology, as well as mRNA-based strategies, utilization of another type of immune cells such as the natural killer cells, as well as incorporating gene editing strategies. A large number of studies, including preclinical and clinical trials, are conducted to translate the findings from the bench to the bedside. The chapter discusses the CAR-T cell therapy, the mechanism, approved therapies, limitations, including toxicities, and resistance, and recent advancements in research, particularly in the therapy of B-cell cancers.Item Sirtuins in inflammation and autoimmunity(Academic Press, 2026) Mirunalini Gobinath , Parikshit Roychowdhury , Sagarika Mukherjee , Mohd Aftab SiddiquiSirtuins, a conserved family of nicotinamide adenine dinucleotide-dependent deacetylases, are key regulators of immune balance, inflammation, and autoimmunity. This chapter examines the dual functions of sirtuin isoforms (SIRT1–SIRT7) in controlling innate and adaptive immunity via transcriptional and posttranslational mechanisms. They affect critical inflammatory pathways, such as NF-κB, STAT3, and NLRP3 inflammasome activation, influencing cytokine, chemokine, and adhesion molecule expression. SIRT1 suppresses proinflammatory genes by deacetylating NF-κB p65, while SIRT6 impacts TNF-α secretion and macrophage polarization. The chapter discusses the variation in sirtuin expression and function in autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. Animal models lacking sirtuins offer insights into autoimmune development and inflammation resolution. The potential of sirtuin modulators such as resveratrol, SRT2104, and other compounds is evaluated using preclinical and clinical data. The chapter also addresses challenges such as tissue specificity, isoform selectivity, and context-dependent effects that hinder clinical translation. Overall, it emphasizes the promising yet complex role of sirtuins as therapeutic targets for inflammation and autoimmunity, emphasizing the need for further research.Item The role of sirtuins in cancer progression(Elsevier Inc., 2026) Anas Islam, Usama Ahmad, Mohd Muazzam Khan, Talib HussainSirtuins represent a highly conserved family of nicotinamide adenine dinucleotide (NAD⁺)-dependent deacetylases that have emerged as pivotal regulators at the intersection of cellular metabolism, epigenetic regulation, and cancer biology. First identified as the mammalian orthologs of yeast Silent Information Regulator 2 (Sir2), the seven mammalian sirtuins (SIRT1–SIRT7) share a conserved catalytic core domain of approximately 275 amino acids yet exhibit remarkable functional diversity through distinct subcellular localizations, enzymatic activities, and substrate specificities. This evolutionary conservation from bacteria to mammals highlights their fundamental importance in cellular homeostasis and organismal survival. In the context of cancer, sirtuins have garnered substantial attention over the past two decades not merely as metabolic sensors, but as master regulators whose dysregulation profoundly influences tumor initiation, progression, and therapeutic response.Item Meat Composition and Nutrition(CRC Press/Apple Academic, 2026) Owais Yousuf, Kaiser Younis, Khwaja OsamaThe world of meat, as a fundamental aspect of human nutrition and culture, is both rich and complex. This new volume illuminates this complexity, comprehensively exploring the biochemical makeup, nutritional properties, and broader implications of meat consumption. Recently, meat discussions have evolved beyond mere sustenance to encompass many issues, including health, ethics, sustainability, and economics. Against this backdrop, understanding the composition of meat and its nutritional significance becomes paramount.Item Biopolymer-based Chemotherapeutics: Combination Therapies and Synergistic Effects(Bentham Science, 2025) Rufaida Wasim, Tarique Mahmood, Saba Parveen, Aamir Anwar, Asad AhmadApplications of nanotechnology have increased the importance of research and nanocarriers, which have revolutionized medication delivery in recent years to treat a range of diseases, including cancer. Due to its multidrug resistance to several chemotherapeutic treatments, cancer, one of the most dangerous diseases in the world, has drawn the attention of experts. Scientists have created a different way to deliver chemotherapeutic drugs to the desired location while reducing side effects and enhancing delivery efficacy on healthy cells by incorporating them into nanocarriers such as synthetic polymers, nanotubes, micelles, dendrimers, magnetic nanoparticles, Quantum Dots (QDs), lipid nanoparticles, nano-biopolymeric substances, etc. Nanotechnology applications have made research and nanocarriers—which have recently transformed drug delivery to treat a variety of illnesses, including cancer—even more crucial. One of the most deadly illnesses in the world, cancer, has caught the attention of scientists because of its multidrug resistance to several chemotherapeutic therapies. By integrating chemotherapeutic drugs into nanocarriers like synthetic polymers, nanotubes, micelles, dendrimers, magnetic nanoparticles, Quantum Dots (QDs), lipid nanoparticles, nano-biopolymeric substances, etc., researchers have developed an alternative method of delivering these medications to the intended site while minimizing side effects and improving delivery efficacy on healthy cells. Preclinical and clinical research on cancer treatment has yielded promising results. Biopolymers stand out as viable options for anticancer nano drug delivery systems due to their exceptional biocompatibility. Moreover, the presence of ligands in some biopolymers that are naturally present on the surface of human cells enables active targeting.Item The Circadian System and Biological Rhythms(CRC Press, 2026) Rufaida Wasim, Elena Zaahu, Tarique Mahmood, Aamir Anwar, Abdulaziz S. SacedanAn important biological mechanism that controls the timing of many physiological and behavioral processes throughout the day is the circadian clock. The hypothalamic suprachiasmatic nucleus (SCN), the master clock that masters the rhythmic production of genes, hormones, and other functions, lies at the hub of this system. Hormone release, body temperature, metabolism, and the sleep-wake cycle are all regulated by circadian rhythms. These rhythms, which assist the body's internal timekeeping system stay in sync with the outside world, are regulated by both internal biological clocks and external environmental cues like light and darkness. Circadian rhythms ensure the body's physiological processes align with the day-night cycle, which is essential for maintaining optimal health. Sleep disorders, metabolic irregularities, cardiovascular ailments, and mental disorders may all result from disruptions to these cycles brought on by shift work, and extreme sleep deprivation. Studies have also connected the onset of chronic illnesses like diabetes and cancer to abnormalities of the circadian clock. Enhancing medical research and public health necessitates a perception of the molecular mechanisms underlying circadian rhythms and how they react to environmental stimuli. The devastating effects of circadian disruption may be debilitated by interventions like behavioral changes meant to maximize or restore circadian rhythms. This chapter discusses the circadian system's evolution, function, impact on biological cycles, and implications for both health and illness.Item Synergism in Nutraceutical Formulations(Springer nature, 2025) Mohd Aftab Siddiqui; Mrunalini Gobinath, Sagarika Mukherjee, Rania I. M. Almoselhy, Afreen Usmani, Rajakumari Rajendran, Sabu Thomas, and Manisha BihanNutraceuticals are bioactive compounds or functional foods consumed to sustain nutrition and support disease prevention. Derived from nutrition and pharmaceuticals, the concept merges food science with therapeutic potential. Synergism in nutraceutical formulations arises when two or more bioactive agents interact to produce enhanced pharmacological or physiological outcomes that surpass the sum of their individual effects. This principle addresses key challenges of monotherapy: poor bioavailability, limited target specificity, and rapid metabolic degradation by enabling multicomponent, mechanistically complementary formulations. Recent innovations such as nano-encapsulation and codelivery systems further enhance absorption, stability, and efficacy of synergistic blends. This chapter provides a comprehensive overview of molecular and formulation-based synergism in nutraceuticals, focusing on mechanistic interactions, formulation challenges, and future directions toward supernutraceuticals that integrate advanced bioengineering and traditional dietary wisdom.Item Chronotherapy in Cardiovascular Disease(Location Boca Raton, 2025) Zahra Sufwan, Javed Akhtar Ansari, Nortoji Khujamshukurov, Mohemmed Faraz KhanChronotherapy, aligning medication timing with the body’s biological rhythms, shows promise in improving cardiovascular disease (CVD) treatment. By tailoring drug schedules to circadian patterns in blood pressure, heart rate, and coagulation, it enhances therapeutic effectiveness while reducing side effects. This approach is explored in managing conditions like hypertension, heart failure, myocardial infarction, and arrhythmias. The chapter explores how circadian rhythm disruptions impact cardiovascular health and disease progression. It highlights the pharmacokinetics and pharmacodynamics of cardiovascular drugs, emphasizing optimized dosing schedules. For instance, nighttime antihypertensives better manage morning blood pressure surges, while evening statin use aligns with peak cholesterol synthesis for improved lipid control. This chapter explores practical aspects of chronotherapy, including challenges like patient adherence and variability in circadian responses. It also highlights advancements in personalized chronotherapy, such as wearable devices and digital tools for monitoring rhythms, paving the way for customized treatment plans. This chapter examines the science of chronotherapy in cardiovascular care, providing healthcare professionals with insights on how strategic medication timing enhances patient outcomes. With increasing evidence of its benefits, chronotherapy could revolutionize cardiovascular treatment, offering more personalized and effective approaches for chronic conditions.Item International Conference on Novel Paradigms in Pharmaceutical Sciences: An Approach for Healthier World (ICNPPS-2024)(Pedatrix Global Solutions, Lucknow, 2024) Javed Akhtar Ansari; Syed Misbahul Hasan, Juber Akhtar, Prof. Tarique Mahmood Ansari, Kuldeep Singh, Vaseem A. Ansari, Badruddeen, Poonam Kushwaha, Ahsan Ahmad KhanThe Faculty of Pharmacy of Integral University organized two days International Conference on “Novel Paradigms in Pharmaceutical Sciences: an Approach for Healthier World”, dated 9-10 March, 2024. Pharmaceutical sciences have been evolving rapidly in recent years. The focus has shifted from traditional drug discovery and development to more innovative approaches that are aimed at improving patient outcomes. The goal of the conference was to bring together academics and researchers from all areas of pharmaceutical sciences and other related fields and to provide a potential platform for exchanging and updating your knowledge in pharmaceutical and health sciences research and innovation. It offered exciting scientific programs that covered all aspects of pharmaceutical sciences from its basics to their applications. The conference also gave attendees a clear knowledge of the problems caused by advance pharmaceuticals, as well as potential solutions. It was an excellent forum for students, postdoctoral fellows, established scientists, faculties, and industry delegates from India and abroad, to exchange ideas and expand their knowledge. It was an excellent occasion to meet researchers from India and across the globe and provided a platform to widen professional contact and create new opportunities, including establishing new collaborations. This strategic conference provided in-depth presentations and interactive sessions, for the possibility to network with like-minded professionals and discuss how to overcome the current challenges in pharmaceutical sciences. The conference was also been planned to have oral and poster presentation sessions from the academic and industry delegates, researchers, and other potential resource personnel.Item Role of Medicinal Plant-Derived Nanoparticles Against Chronic Diseases(Springer, Cham, 2025) Mohd Aftab Siddiqui, Mohammad Saidurrahman, Afreen UsmaniMedicinal herbs have been discovered to contain medicinal properties, and the development in nanotechnology has improved their efficiency toward healing chronic diseases. This chapter discusses the synthesis and use of nanoparticles (MPNPs) from medicinal plants for treating diseases like diabetes, cardiovascular disease, cancer, neurodegenerative diseases, and inflammation. These nanoparticles are more bioavailable, site-directed, and less systemically toxic, avoiding the limitations of conventional treatment. The primary mechanisms of action include antioxidant, anti-inflammatory, and antimicrobial activity, as well as modulating key cellular pathways. The chapter also emphasizes pioneering nanoparticle synthesis approaches, including green and biogenic synthesis, and highlights their benefits as scalable and eco-friendly. Stability concerns, regulatory implications, and clinical translation are also discussed, along with directions for future studies to maximize the potential of MPNPs in personalized medicine.