Faculty Publications
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Scholarly Publications by Integral Academia
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Item Role of Medicinal Plant-Derived Nanoparticles Against Chronic Diseases(Springer, Cham, 2025) Mohd Aftab Siddiqui, Mohammad Saidurrahman, Afreen UsmaniMedicinal herbs have been discovered to contain medicinal properties, and the development in nanotechnology has improved their efficiency toward healing chronic diseases. This chapter discusses the synthesis and use of nanoparticles (MPNPs) from medicinal plants for treating diseases like diabetes, cardiovascular disease, cancer, neurodegenerative diseases, and inflammation. These nanoparticles are more bioavailable, site-directed, and less systemically toxic, avoiding the limitations of conventional treatment. The primary mechanisms of action include antioxidant, anti-inflammatory, and antimicrobial activity, as well as modulating key cellular pathways. The chapter also emphasizes pioneering nanoparticle synthesis approaches, including green and biogenic synthesis, and highlights their benefits as scalable and eco-friendly. Stability concerns, regulatory implications, and clinical translation are also discussed, along with directions for future studies to maximize the potential of MPNPs in personalized medicine.Item An Introduction to Bioprocessing and Industrial Bio-Manufacturing Foundation and Evolution(IGI Global Scientific Publishing, 2025) Rabin Debnath, Mohd Aftab Siddiqui, Tapoban Bordoloi, Izaz Hussain, Sneha Parbin, Mostafa Khursid Alam, Sachin Kumar, Shriyansh Srivastava, Rakesh SahuThis chapter highlights the transformative potential of bioprocessing and biomanufacturing as central forces in biotechnology, ecology, and medicine. Bioprocessing is the foundation of modern biotechnology because it actively employs biological systems to produce valuable compounds while simultaneously addressing urgent global challenges. Through carefully designed processes, bioprocessing mitigates climate change, strengthens ecosystem resilience, and responds to the escalating demands of global population growth by enabling sustainable production of food, medicines, and renewable energy.Item Chronopharmacology: Time-Dependent Pharmacotherapy(CRC Press, 2025) Mohd Aftab Siddiqui, Afreen Usmani, Mohd Nazam AnsariChronopharmacology: Time-Dependent Pharmacotherapy explores the cutting-edge science of tailoring drug administration to the body's natural biological rhythms, known as circadian rhythms. This comprehensive book provides healthcare professionals and researchers a deep understanding of how the timing of drug administration can impact therapeutic efficacy, safety, and patient outcomes. By integrating knowledge from pharmacology, chronobiology, and clinical medicine, the book offers both theoretical insights and practical guidelines for applying chronopharmacology in the treatment of diseases like cardiovascular disorders, cancer, and sleep-related conditions. Through case studies and the latest research on circadian-based drug delivery systems, this text is an invaluable resource for clinicians aiming to optimize patient care and researchers exploring new frontiers in personalized medicine.Item Gut Microbiota and Colorectal Cancer Pathogenesis(Humana, Cham, 2025) Anas Islam, Badruddeen, Mohammad Irfan Khan, Mohsin Vahid Khan, Yusuf AsadThis chapter explores the complex relationship between the gut microbiota and the pathogenesis of colorectal cancer (CRC), highlighting the role of microbial dysbiosis in promoting inflammation, DNA damage, and immune dysregulation. It reviews key pro-carcinogenic bacteria, such as Fusobacterium nucleatum, Bacteroides fragilis, and pks+ Escherichia coli, which contribute to tumor initiation and progression. The chapter also discusses the protective effects of beneficial microbes like Lactobacillus and Bifidobacterium, which help maintain gut health and inhibit carcinogenesis. Therapeutic strategies aimed at modulating the gut microbiota, including dietary interventions, probiotics, prebiotics, fecal microbiota transplantation (FMT), and postbiotics, are examined for their potential in CRC prevention and treatment. Finally, future directions in personalized microbiome-based therapies, diagnostic biomarkers, and the challenges facing clinical translation of gut microbiota research are addressed. The chapter emphasizes the growing importance of targeting the microbiome in CRC management to enhance prevention, diagnosis, and therapeutic outcomes.Item Antimicrobial Resistance: An Unknown Threat to Humankind(Integrated Publications, 2024) Sahil Hussain, Arun Kumar, Kuldeep Singh, Shom Prakash Kushwaha, Mohd. Mursal, Mohd. ShainoorWith resistance found to every antibiotic now in clinical use and only a handful of innovative treatments in the development, antibiotic resistance is a worldwide health disaster. Understanding the molecular mechanisms that bacteria use to withstand the effects of antimicrobials is essential for identifying global patterns of resistance, optimising the use of existing medications, designing new medications that are less likely to develop resistance, and developing cutting-edge methods to combat resistance. In this review, we look at recent developments in our knowledge of how resistance genes affect the biology of the host, as well as new structural information on important molecular processes that underlie resistance, various mechanism of resistance and method of destruction of antibiotic through variety of different enzymatic action and other methods involved such as efflux and conformational changes that are adopted by the bacteria and other microorganism to combat antibiotics. Finally, we go over how we can apply this knowledge to create the newest antimicrobial treatments.Item Innovations in Pharmaceutical Technology: Transforming Drug Discovery and Development(M/S Academic Publishers & Distributors, Lucknow, India, 2025) Pradip Kumar, Pankaj Bhatt, Monowar Alam Khalid, Juber Akhtar, Ravikant SinghThe field of pharmaceutical technology is advancing rapidly, with groundbreaking innovations in drug discovery and development transforming modern medical sciences. These advancements are not only revolutionizing treatment methodologies but also driving the development of more precise, effective, and personalized therapeutic solutions. This book, Innovations in Pharmaceutical Technology: Transforming Drug Discovery and Development, serves as a comprehensive reference, compiling cutting-edge research and emerging trends that are shaping pharmaceutical and biomedical sciences. With twelve meticulously curated chapters, this volume explores advanced pharmaceutical technologies, bridging the gap between traditional approaches and modern scientific breakthroughs. Key areas covered include 3D Printing, Quantum computing, Drug testing, drug discovery and development, microbiome targeted therapies, AI and ML in drug designs and stem cell and tissue engineering. We are deeply grateful to the renowned researchers and scholars whose contributions have enriched this volume. Their expertise has made this book a valuable resource for academics, researchers, and industry professionals. We extend our sincere appreciation to our colleagues and university authorities for their unwavering support and encouragement. Lastly, we express our heartfelt gratitude to our families and friends for their patience, motivation, and support throughout this endeavour. We hope this book serves as an inspiration and valuable guide for researchers, scholars, and practitioners, fostering future innovations in drug discovery, development, and pharmaceutical technology.Item Quality assurance framework for smart drug delivery systems in pharmaceutical industries and its applications(CRC Press, 2024) Sara Khan, Juber Akhtar, Muhammad Farhan, Nortoji A. Khujamshukurov, Badruddeen, Mohammad Irfan Khan, Mohammad Ahmad, Zainab FatimaQuality assurance is a key term used in manufacturing industries to ensure the safety, efficacy, stability, reliability, potency, purity, and quality of the products that are delivered to the customers. It ensures that the final product is physically, chemically, and biologically fit for the purpose for which it is developed. Quality assurance framework is basically a method to monitor the quality of a process or the product throughout the process i.e., from the selection of raw material till the production of the required product/drug and prevent mistakes and defects during production and development. Smart systems refer to novel systems or approaches to design and deliver desired drugs/products with minimum side effects, maximum therapeutic potency, and improved patient compliance/acceptability. Hence, the quality-assured framework in smart systems is intended to assure that established quality standards of the final product are met when novel approaches are employed in the development/production of drug delivery systems.Item Management of Gut MicrobiotaDerived Bacterial Metabolites Induced Inflammatory Bowel Disease(Apple Academic Press, 2025) Monika Vishwakarma, Poornima Agarwal, Faheem Haider, Tanweer Haider, Vandana SoniInflammatory bowel disease (IBD) is the most common issue in every generation of individuals due to their eating habits, stress, and unhealthy lifestyle. IBD occurs due to chronic inflammation of digestive tract tissues, mainly characterized by symptoms such as diarrhea, abdominal cramps, blood in stool, etc. Ulcerative colitis and Crohn’s disease are the two variants of IBD that affect the linings of the large intestine, rectum, and gastrointestinal tracts. The human gastrointestinal tract contains trillions of good and bad microorganisms such as bacteria, fungi, viruses, and many others that form gut microbiota. These microorganisms use dietary substances to form metabolites that maintain a healthy gut environment. Excessive use of antibiotics and a high intake of a westernized diet have led to the degradation of good gut bacteria and an increase in the count of bad bacteria, which release harmful metabolites such as bile acids, short-chain fatty acids, tryptophan metabolites, and sphingolipids. These metabolites induce several diseases, of which IBD is one. Prebiotics, probiotics, and fecal microbiota transplantation are employed for treating bacterial-induced IBD. In this chapter, we will discuss the bacterial metabolites that induce IBD and its treatment strategy.Item Smart Nanomaterials in Drug Delivery for Cancer Therapy(Springer, Singapore, 2025) Asim Rahman, Nazish Naseem, Amreen Fatima, Md. Faheem HaiderIn today’s world, one of the leading diseases people are facing is cancer, and liver cancer is one of them. Though various drugs acting via different mechanisms of action are present in the market as conventional formulations for the treatment of liver cancer they face substantial challenges regarding their bioavailability, low solubility and associated adverse effects which greatly limit their therapeutic efficacies. Nanotechnology has emerged as a promising tool for cancer therapy. Smart nanomaterials, in particular, have gained significant attention due to their unique properties, such as high surface area, biocompatibility, and the ability to be functionalized with targeting moieties. Smart nanomaterials can be designed to selectively deliver drugs to cancer cells, improve drug efficacy, and reduce toxicity. Various studies exhibit that nanocarriers can significantly increase drug bioavailability and increase solubility. The present chapter summarizes nanoformulations used in the treatment of liver cancer. It also highlights the available therapeutics in the market which is used for the treatment of liver cancer along with their side effects and drawbacks and how nanoformulation can overcome these drawbacks of present therapeutics.Item Pulmonary drug delivery of lipid-based formulations via nebulizers(Elsevier Inc., 2025) Anas Islam, Ambareen Fatima Ahmed, Widhilika Singh, , Usama Ahmad, Asad Ahmad, Mohd Muazzam Khan, Md FaiyazuddinNebulizers are medical equipment that transform liquid drugs into inhaled aerosols. They are widely utilized in the management of respiratory conditions such cystic fibrosis, asthma, and chronic obstructive pulmonary disease (COPD). Compared with alternative pulmonary drug delivery methods, lipid-based nebulizers have several benefits, such as the capacity to encapsulate medications and shield them from deterioration, as well as their safety and biocompatibility profiles. The goal is to emphasize the potential of lipid-based nebulizers as a viable drug delivery technology for the treatment of respiratory disorders and to explain the benefits of employing lipid-based formulations for pulmonary medication delivery. The chapter discusses the several types of nebulizers and their applications, as well as formulation development, nebulizer performance, and clinical applications. The importance of this chapter stems from its ability to aid researchers and physicians in the development and deployment of lipid-based nebulizers for pulmonary medication delivery, resulting in enhanced treatment choices for patients with respiratory disorders.