Faculty Publications

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Scholarly Publications by Integral Academia

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Start date: 2023Subject: search.filters.subject.liposomes

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    Combination Drug Delivery Using Nanocarriers
    (IJPHI Global Publisher Pvt. Ltd., 2026) Mohd Maaz Khan, Nitin Pandey, Anam Siddiqui, Himanshu Singh
    Combination drug delivery using nanocarriers is an emerging approach designed to improve the efficacy and safety of drug therapy. In many diseases, especially cancer and infectious disorders, the use of more than one drug is required to achieve better therapeutic effects. However, different drugs may have different solubility, stability, absorption, and distribution properties, making their combined delivery challenging. Nanocarriers provide an effective platform for overcoming these limitations by carrying two or more drugs within the same delivery system and releasing them at the desired sites. Various nanocarriers, including liposomes, polymeric nanoparticles, lipid nanoparticles, micelles, dendrimers, nanogels, and hybrid systems, have been investigated for combination therapies. These systems can improve drug solubility, protect drugs from premature degradation, enhance cellular uptake, and provide controlled or sustained drug release. Targeting strategies can further increase drug accumulation in diseased tissues and reduce unwanted exposure to healthy ones. An important advantage of combination nanocarriers is their ability to maintain a suitable ratio of different drugs, which may enhance synergistic activity and reduce drug resistance. Despite these benefits, several challenges remain, including formulation stability, drug compatibility, reproducible drug loading, toxicity, large-scale manufacturing, and regulatory approvals. Recent advances in nanotechnology and biomaterials have provided new opportunities for developing safer and more effective combination delivery systems. This chapter discusses the basic concepts, major types of nanocarriers, formulation approaches, mechanisms of drug co-delivery, therapeutic applications, current challenges, and future prospects of combination drug delivery using nanocarriers.
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    Liposomes: History, Properties, and Applications
    (Nova Science Publishers, Inc, 2024) Shivangi Sharma, Anas Islam, Mohd Muazzam Khan, Usama Ahmad
    The use of liposomes in nanotechnology has become more widespread in recent years. Liposomes are self-assembled particles having a water chamber that is surrounded by a lipid bilayer. This chapter has covered the liposomes in great detail, including how and where they were created, a broad description of their structure, and what distinct types of lipids they are composed of. Depending on their size, liposomes can be classified into several distinct varieties, such as enormous liposomes, multilamellar liposomes, and unilamellar liposomes. Depending on the context, different liposomes can be produced using various preparation techniques. In this chapter, we have also learned about the several fields in which liposomes have been extensively employed for the treatment of various diseases, biotechnology research, cosmetic items, nutraceuticals, and food. To increase the stability of the core, liposomes are important in the encapsulation of a variety of bioactive compounds (BACs), including functional food additives. In this chapter, we have also discussed the future perspective and scope where liposome technology can be exploited, the different fields in which liposome nanotechnology can be a boon, and the revolution it can make in pharmaceuticals.
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    Perspective Chapter: Nose-to-Brain Drug Delivery through Liposomes - Recent Applications
    (IntechOpen, 2023) Abdul Hafeez; Shazia Afzal Usmani
    Diseases related to the brain are causing a huge problem worldwide. Different drug formulations are available for the management of brain-related disorders, but due to less drug availability for the brain and non-specificity, it becomes difficult to completely cure life-threatening brain disorders. The blood-brain barrier (BBB) restricts the entry of drug molecules/drug-loaded carriers because of the presence of various efflux transporters and drug inactivating enzymes. Researchers have identified an intranasal route for direct delivery to the brain, bypassing BBB. Nanotechnology-enabled lipid-based drug carrier systems have shown potential for the management of brain diseases through nose-to-brain delivery. Liposomes are the most extensively investigated carrier systems because of biocompatibility, controlled release characteristics, easy surface modification, and biodegradability. This chapter highlights the important aspects of nose-to-brain delivery and strategies for enhancing the availability of drugs through liposomes in the management of different brain-related diseases.