Faculty Publications
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Scholarly Publications by Integral Academia
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Item Ultrasound-Responsive Delivery Nanoplatforms in Cancer Theranostics(CRC Press, 2024) Vaseem Ahmad Ansari; Ruchi Tiwari,Juhi Mishra and Namdev L. DhasNanotechnology is being used widely because inventive nanocarriers enhance the functionality and effectiveness of chemotherapy. A chemotherapeutic agent released from ultrasonic-responsive nanocarriers is triggered by the vibration of ultrasound (US), which creates microscopic gas bubbles that alter the permeability of cell membranes and raise pressure. This chapter covers new nanomaterials that have been employed for both cancer treatment and diagnostics and are ultrasound sensitive. Deep tissue penetration, spatiotemporal control, and the induction of tumour cell apoptosis and necrosis are all possible with the use of localized, non-ionizing, non-invasive US. US delivery relies mostly on sonoporation, cavitation, and hyperthermia. Drug-loaded nanoparticles may be created with the goals of increasing effectiveness and lowering toxicity. Mesoporous silica nanoplatforms, microbubbles, nanobubbles, micelles, gold nanoparticles, hydrogels, liposomes, niosomes, polymeric nanoparticles, and dendrimers are been covered in depth as theranostic nanocarriers. It can be concluded that nanomaterials may be manufactured in a variety of ways and can be combined to generate hybrids; it will be possible to develop nanostructures that are sensitive to a variety of internal and external triggers. Combining the advantages of external US irradiation with deep tissue penetration is an appealing strategy.Item Regulations in Gulf Cooperation Council (GCC) Countries(CRC Press, 2024) Usama Ahmad; Anas Islam, Vazahat AliThis chapter explores the regulations governing Active Pharmaceutical Ingredient (API) drug products in the Gulf Cooperation Council (GCC) countries. It provides an overview of the GCC countries, defines APIs, and emphasizes the importance of API regulations within the region. The chapter aims to examine the regulatory framework for APIs in the GCC countries, comparing the specific regulations in Saudi Arabia, United Arab Emirates (UAE), Kuwait, Bahrain, Oman, and Qatar. To begin, the chapter delves into the general regulatory landscape surrounding APIs in the GCC countries, outlining the registration and approval processes for these crucial components of pharmaceutical products. It also highlights the post-approval requirements and monitoring mechanisms that ensure the ongoing safety and efficacy of APIs. In a comprehensive comparison, the chapter presents a detailed analysis of API regulations in each GCC country. By exploring the specific regulatory frameworks of the GCC countries, readers gain valuable insights into the similarities, differences, and unique approaches employed by each country. Additionally, the chapter addresses the challenges and issues faced in API regulations within the GCC countries. It explores compliance challenges, quality control concerns, intellectual property considerations, and the difficulties associated with harmonization. Furthermore, the chapter offers a forward-looking perspective by discussing potential future trends that may impact API regulations in the region. In conclusion, this chapter summarizes the key points discussed throughout the analysis. It underscores the significance of API regulations in the GCC countries and their impact on public health and the pharmaceutical industry. Finally, it highlights the potential for future developments in API regulations, emphasizing the need for continued attention and adaptation to meet evolving regulatory requirements and ensure the safety and quality of pharmaceutical products within the GCC countries.Item Therapeutic Impact of Exosomes in Stroke and Transient Ischemic Attack(Springer, Singapore, 2024) Rufaida Wasim; Anas Islam, Asad Ahmad, Aditya Singh, Azhar Mahmood Farooqui ,Yusuf AsadStroke and transient ischemic attack (TIA) are debilitating neurological conditions characterized by a sudden disruption of blood flow to the brain, resulting in tissue damage and functional impairments. Despite extensive research efforts, effective therapeutic interventions for stroke and TIA remain limited. However, recent advancements in the field of exosome-based therapeutics have shown promising potential for the treatment of these brain disorders. Exosomes, small extracellular vesicles secreted by various cell types, have emerged as key mediators of intercellular communication, owing to their ability to transport bioactive molecules and modulate cellular functions. This chapter discusses the therapeutic effects of exosomes in stroke and TIA, elucidating the mechanisms underlying exosome-mediated neuroprotection. Furthermore, the chapter delves into the challenges associated with exosome-based therapies, including limitations and barriers to clinical translation. Strategies to overcome these challenges are discussed, along with emerging trends and future directions in exosome research for stroke and TIA. In conclusion, this chapter highlights the therapeutic impact of exosomes in stroke and TIA, underscoring their potential as a novel and promising avenue for therapeutic intervention. By addressing the current knowledge gaps and exploring future research directions, this chapter aims to contribute to the advancement of exosome-based therapies in clinical practice.Item Epigenetics as Diagnostic and Therapeutic Tool in Neurodegenerative Disorders(Bentham Science, 2024) Rufaida Wasim; Tarique Mahmood, Farogh Ahsan, Aditya Singh, Asad AhmadEpigenetics is a field that is concerned with the investigation of heritable modifications in gene expression that transpire without DNA sequence alterations, thereby establishing a connection between the genome and its surroundings. Epigenetics simply analyzes gene expression amendment beyond variation to the DNA sequence. The gradual accumulation of epigenetic changes over the course of an individual's life span may contribute to neurodegeneration. This chapter deals with epigenetic alteration, which affects the progress of neurodegeneration with age. Epigenetic regulation, encompassing DNA methylation and histone modification, has been implicated in the anomalous alterations in gene expression that occur during the progression of neurodegeneration. The concept of epigenetics is useful to synthesize novel medications to target these disorders. In recent times, a plethora of epigeneticsbased medications have been developed for the treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Due to a major lack of early screening processes that allow therapeutic agents to be distributed to afflicted neurons paramount to cell death, many neurological conditions have severely restricted options for treatment. Significant progress has been seen in neurodegenerative disease biomarkers. These biomarkers have been unfortunate, due to substantial disparities amidst the tissues acclimated to source biomarkers and biomarkers of disease. Neurodegeneration may be exacerbated by epigenetic changes that develop gradually. Epigenetic biomarkers could aid in the diagnosis, and monitoring, of neurodegenerative diseases.Item Dendrimers in the management of Alzheimer's disease(Academic Press, 2024) Aditya Singh; Chetna Modi , Bhupendra Gopalbhai Prajapati , Sudarshan Singh , Shubhrat MaheshwariAlzheimer's disease (AD) is a progressive neurological disorder that affects the brain and leads to decline in cognitive function, memory, thinking, behavior. Alzheimer's disease is the most common cause of dementia, accounting for 60%–80% of all cases. The exact cause of AD is still not fully, however it is thought to involve a combination of genetic, environmental, and lifestyle factors. There is currently no exact medication and drug delivery available that can cure for AD, but there are several treatments available that can help in managing symptoms and slow the progression of the disease. These treatments include medication, behavioral interventions, and lifestyle changes, such as exercise and a healthy diet. Additionally, ongoing research is focused on developing nanotechnology-based new therapies and approaches such as nanoparticles, solid lipid nanoparticles, vesicular drug delivery, and dendrimers to prevent, slow, or cure AD. with Dendrimers in AD act as carrier for drug that target the β-amyloid plaques and T-tangles that are characteristic of the characteristic of the disease. Dendrimers can conjugate with drugs, enabling them to be delivered to the brain and penetrate the blood-brain barrier. Moreover, dendrimers have been reported as imaging agent that help in detection and monitoring the progression of AD. In this chapter a brief overview on dendrimers synthesis, characterization, and conjugation with drugs for treatment and management AD elaborated.Item Targeted Drug Delivery to Combat Antibacterial Drug Resistance(IGI Global, 2024) Kuldeep Singh; Nitin Pandey,Shom Prakash Kushwaha, Arun Kumar, Mohammad Khalid, Ahsan Ahmed Khan, Maaz KhanIn targeted drug delivery, antibiotics are precisely delivered to infection areas using nanoparticles and carrier systems, increasing effectiveness, lowering side effects, and causing the least amount of damage to the microbiota. By increasing local antibiotic concentrations, releasing antibiotics selectively depending on bacterial indicators, and using synergistic combination treatments, this approach combats antibacterial resistance. Diagnostics, real-time monitoring, and responsive medication delivery are all combined on multifunctional platforms made possible by nanotechnology. Though problems like biocompatibility and regulatory barriers still exist, recent research has shown promise both in vitro and in vivo. Targeted drug delivery, subject to additional study and invention, offers a method to increase antibiotic effectiveness while tackling resistance. It promises to improve the management of infectious diseases. Targeted distribution can address a variety of problems related to antibacterial resistance.Item Outer Membrane Permeability Enhancer(IGI Global, 2024) Kuldeep Singh; Mo Shahanawaz,Shom Prakash Kushwaha, Arun Kumar, Suvaiv, ShafiurrahmaBacterial resistance poses a significant threat to global healthcare systems and requires innovative solutions to combat this growing problem. In this context, the concept of outer membrane permeability enhancers has emerged as a promising strategy. The gram-negative bacteria's outer membrane acts as a robust defense mechanism, limiting the effectiveness of antibiotics. The introduction of outer membrane permeability enhancers aims to address this challenge by enhancing the permeability of the outer membrane, thus facilitating the entry of antibiotics into bacterial cells. In this chapter, the authors explore the intricacies of outer membrane permeability enhancers like EDTA, polymyxins, aminoglycosides, and tris or tris (hydroxymethyl) aminomethane and their potential impact on bacterial resistance. The outer membrane's composition, comprising lipopolysaccharides, proteins, and phospholipids, creates a formidable barrier that many antibiotics struggle to penetrate.Item Liposomes: Advances in Research and Applications(Nova Science Publishers, 2024) Usama Ahmad; Anas IslamLiposomes: Advances in Research and Applications is a comprehensive exploration of the evolving landscape of liposome science. This meticulously crafted book encompasses a spectrum of topics, ranging from the historical context and versatile properties of liposomes to their recent developments and challenges in drug delivery. The book delves into the crucial role of liposomes in cancer therapy, examining the current state and outlining future directions, with a specific focus on breast cancer, cervical cancer, and ovarian cancer therapy. Furthermore, it explores the innovative applications of liposomes in gene delivery, providing insights into methods and real-world applications. As a cohesive resource, this book serves as an indispensable guide for researchers, clinicians, and students, offering a nuanced understanding of liposomal advancements and their potential in shaping the future of drug delivery, cancer treatment, and gene therapy.Item Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases(Bentham Science, 2024) Tarique Mahmood Ansari; Anuradha Mishra, Preeti BajpaiItem HUMAN ANATOMY AND PHYSIOLOGY -1(Alpha International Publications, 2024) SHABANA KHATOON; MAHIMA CHAUHAN , YARRA SAI PHANINDRA,SAURABH SHEKHAR