Faculty Publications

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Scholarly Publications by Integral Academia

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Start date: 2025Subject: search.filters.subject.Anticancer

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    PHARMACOLOGICAL POTENTIAL OF NATURALLY DERIVED CHALCONES
    (Tashkent Institute of Chemical Technology, 2026) Haroon Ahmad Khan, Saimah Khan
    Chalcones are naturally occurring polyphenolic compounds belonging to the flavonoid family and are widely distributed in fruits, vegetables, spices, and medicinal plants. Due to their simple chemical structure and diverse biological activities, naturally derived chalcones have attracted significant attention in pharmaceutical and medicinal research. This review aims to summarize the pharmacological potential of naturally occurring chalcones and highlight their therapeutic applications. Extensive studies have demonstrated that chalcones exhibit a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antimicrobial, antiviral, anticancer, antidiabetic, and neuroprotective effects. These activities are primarily attributed to their ability to modulate various cellular signaling pathways, inhibit enzyme activity, regulate oxidative stress, and influence inflammatory mediators. Furthermore, naturally derived chalcones have shown promising efficacy in preclinical studies against several chronic and infectious diseases, suggesting their potential as lead compounds for drug development. Recent advances in structural modification and molecular docking studies have further enhanced the understanding of their mechanism of action and pharmacological properties. Despite encouraging findings, challenges related to bioavailability, toxicity, and clinical validation remain to be addressed. Overall, naturally derived chalcones represent a valuable class of bioactive molecules with considerable therapeutic potential, warranting further investigation for the development of safe and effective pharmaceutical agents.
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    Smart Nanomaterials in Drug Delivery for Cancer Therapy
    (Springer, Singapore, 2025) Asim Rahman, Nazish Naseem, Amreen Fatima, Md. Faheem Haider
    In today’s world, one of the leading diseases people are facing is cancer, and liver cancer is one of them. Though various drugs acting via different mechanisms of action are present in the market as conventional formulations for the treatment of liver cancer they face substantial challenges regarding their bioavailability, low solubility and associated adverse effects which greatly limit their therapeutic efficacies. Nanotechnology has emerged as a promising tool for cancer therapy. Smart nanomaterials, in particular, have gained significant attention due to their unique properties, such as high surface area, biocompatibility, and the ability to be functionalized with targeting moieties. Smart nanomaterials can be designed to selectively deliver drugs to cancer cells, improve drug efficacy, and reduce toxicity. Various studies exhibit that nanocarriers can significantly increase drug bioavailability and increase solubility. The present chapter summarizes nanoformulations used in the treatment of liver cancer. It also highlights the available therapeutics in the market which is used for the treatment of liver cancer along with their side effects and drawbacks and how nanoformulation can overcome these drawbacks of present therapeutics.