Faculty Publications

Permanent URI for this communityhttp://192.168.24.11:4000/handle/123456789/7

Scholarly Publications by Integral Academia

Browse

Filters

2025 - 20262

Settings

Has files: YesSubject: search.filters.subject.Nanocarriers

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Liver Targeting Strategies with Nanocarriers
    (Bentham Science, 2026) Afreen Usmani, Mohd Aftab Siddiqui, Mohd Nazam Ansari, Rania I.M. Almoselhy
    Fatty liver diseases, including nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), have emerged as some of the most prevalent causes of chronic liver disorders worldwide. Treatment options remain limited due to poor drug bioavailability and nonspecific targeting, resulting in suboptimal therapeutic outcomes. In this context, nanocarriers have shown significant promise by improving drug delivery, enabling precise targeting, and thereby enhancing therapeutic efficacy in the management of fatty liver diseases. This chapter offers a comprehensive review of liver-targeting strategies using nanocarriers, with particular attention to the complexity of fatty liver disease. It examines various nanocarrier systems, such as liposomes, polymeric nanoparticles, dendrimers, and lipid-based carriers, focusing on their structural features and potential for targeted drug delivery. Emerging strategies, including receptor-mediated and stimulus-responsive delivery systems, are critically analyzed. Furthermore, this chapter explores the integration of nanocarriers with cutting-edge technologies, such as RNA-based therapeutics and CRISPR-Cas9 gene editing. Issues related to scalability, safety, and regulatory challenges are also discussed, alongside the latest advancements in preclinical and clinical research. Overall, this chapter serves as a valuable resource, outlining current knowledge and future directions for researchers, clinicians, and pharmaceutical developers working to advance liver-targeted therapies for fatty liver diseases.
  • Thumbnail Image
    Item
    Synergism in Nutraceutical Formulations
    (Springer nature, 2025) Mohd Aftab Siddiqui; Mrunalini Gobinath, Sagarika Mukherjee, Rania I. M. Almoselhy, Afreen Usmani, Rajakumari Rajendran, Sabu Thomas, and Manisha Bihan
    Nutraceuticals are bioactive compounds or functional foods consumed to sustain nutrition and support disease prevention. Derived from nutrition and pharmaceuticals, the concept merges food science with therapeutic potential. Synergism in nutraceutical formulations arises when two or more bioactive agents interact to produce enhanced pharmacological or physiological outcomes that surpass the sum of their individual effects. This principle addresses key challenges of monotherapy: poor bioavailability, limited target specificity, and rapid metabolic degradation by enabling multicomponent, mechanistically complementary formulations. Recent innovations such as nano-encapsulation and codelivery systems further enhance absorption, stability, and efficacy of synergistic blends. This chapter provides a comprehensive overview of molecular and formulation-based synergism in nutraceuticals, focusing on mechanistic interactions, formulation challenges, and future directions toward supernutraceuticals that integrate advanced bioengineering and traditional dietary wisdom.