Faculty Publications

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    Nanotechnology based Transdermal Drug Delivery
    (IJPHI Global Publisher Pvt. Ltd., 2026) Manisha Mishra, Pooja Pradhan, Himanshu Sign
    Transdermal drug delivery systems have gained significant attention as an alternative to conventional routes because of their ability to bypass first-pass metabolism and provide controlled drug release. However, the major limitation of traditional transdermal systems is the barrier function of the stratum corneum, which restricts the permeation of many therapeutic agents. To overcome this challenge, nanotechnology-based approaches have been widely explored. Nanocarriers, such as nanoparticles, liposomes, niosomes, and nangemulsions, enhance drug permeation through the skin by improving solubility, stability, and controlled-release characteristics. These nangsystems interact with the skin at the molecular level, facilitating deeper penetration and targeted delivery of drugs. Additionally, they can reduce the dosing frequency and minimize systemic side effects, thereby improving patient compliance. In this approach, the formulation and optimization of nanocarrier-based transdermal systems focus on parameters such as particle size, surface charge, drug entrapment efficiency, and release kinetics. The integration of nanotechnology with transdermal delivery offers a promising platform for delivering a wide range of drugs, including poorly soluble and potent molecules. Overall, nanotechnology-based transdermal drug delivery represents an advanced and effective strategy for achieving enhanced therapeutic outcomes and overcoming the limitations of conventional drug delivery systems.
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    Combination Drug Delivery Using Nanocarriers
    (IJPHI Global Publisher Pvt. Ltd., 2026) Mohd Maaz Khan, Nitin Pandey, Anam Siddiqui, Himanshu Singh
    Combination drug delivery using nanocarriers is an emerging approach designed to improve the efficacy and safety of drug therapy. In many diseases, especially cancer and infectious disorders, the use of more than one drug is required to achieve better therapeutic effects. However, different drugs may have different solubility, stability, absorption, and distribution properties, making their combined delivery challenging. Nanocarriers provide an effective platform for overcoming these limitations by carrying two or more drugs within the same delivery system and releasing them at the desired sites. Various nanocarriers, including liposomes, polymeric nanoparticles, lipid nanoparticles, micelles, dendrimers, nanogels, and hybrid systems, have been investigated for combination therapies. These systems can improve drug solubility, protect drugs from premature degradation, enhance cellular uptake, and provide controlled or sustained drug release. Targeting strategies can further increase drug accumulation in diseased tissues and reduce unwanted exposure to healthy ones. An important advantage of combination nanocarriers is their ability to maintain a suitable ratio of different drugs, which may enhance synergistic activity and reduce drug resistance. Despite these benefits, several challenges remain, including formulation stability, drug compatibility, reproducible drug loading, toxicity, large-scale manufacturing, and regulatory approvals. Recent advances in nanotechnology and biomaterials have provided new opportunities for developing safer and more effective combination delivery systems. This chapter discusses the basic concepts, major types of nanocarriers, formulation approaches, mechanisms of drug co-delivery, therapeutic applications, current challenges, and future prospects of combination drug delivery using nanocarriers.