Faculty Publications

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Scholarly Publications by Integral Academia

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    Molecular Insights and Therapeutic Advances in Breast Cancer
    (Book Rivers, 2026) Heena Bano, Rahul Singh
    Breast cancer is a complex and heterogeneous disease with multifactorial etiologies encompassing genetic, environmental, and lifestyle factors. It stands as one of the most prevalent malignancies affecting women worldwide, characterized by uncontrolled cell proliferation within the breast tissue. Advances in molecular biology have uncovered significant insights into tumorigenesis, including the pivotal roles of genes such as BRCA1/2, p53, and HER2, alongside critical pathways like apoptosis, autophagy, and necroptosis. Contemporary diagnostic approaches integrate traditional methods such as mammography with sophisticated genomic profiling to enable early detection and personalized treatment planning. Therapeutic strategies have evolved from conventional chemotherapy and surgery to include targeted therapies and immunotherapy, enhancing treatment outcomes. However, challenges such as drug resistance, tumor recurrence, and treatment side effects persist. This chapter aims to provide a detailed overview of the mechanisms underlying breast cancer development, molecular diagnostics, current therapeutic interventions, and emerging treatment paradigms.
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    Epigenetics as Diagnostic and Therapeutic Tool in Neurodegenerative Disorders
    (Bentham Science, 2024) Rufaida Wasim; Tarique Mahmood, Farogh Ahsan, Aditya Singh, Asad Ahmad
    Epigenetics is a field that is concerned with the investigation of heritable modifications in gene expression that transpire without DNA sequence alterations, thereby establishing a connection between the genome and its surroundings. Epigenetics simply analyzes gene expression amendment beyond variation to the DNA sequence. The gradual accumulation of epigenetic changes over the course of an individual's life span may contribute to neurodegeneration. This chapter deals with epigenetic alteration, which affects the progress of neurodegeneration with age. Epigenetic regulation, encompassing DNA methylation and histone modification, has been implicated in the anomalous alterations in gene expression that occur during the progression of neurodegeneration. The concept of epigenetics is useful to synthesize novel medications to target these disorders. In recent times, a plethora of epigeneticsbased medications have been developed for the treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Due to a major lack of early screening processes that allow therapeutic agents to be distributed to afflicted neurons paramount to cell death, many neurological conditions have severely restricted options for treatment. Significant progress has been seen in neurodegenerative disease biomarkers. These biomarkers have been unfortunate, due to substantial disparities amidst the tissues acclimated to source biomarkers and biomarkers of disease. Neurodegeneration may be exacerbated by epigenetic changes that develop gradually. Epigenetic biomarkers could aid in the diagnosis, and monitoring, of neurodegenerative diseases.