Faculty Publications

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Scholarly Publications by Integral Academia

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Subject: search.filters.subject.Liver cancer

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    Bioactive Food Compounds Against Liver Cancer
    (Springer, Cham, 2026) Aditya Singh, Shubhrat Maheshwari, Amita Verma, Vaseem A. Ansari, Bhupendra G. Prajapati
    Liver cancer arises from the dysregulated proliferation of hepatic cells and is driven by a multitude of contributing factors, as revealed through advanced cellular biology and comprehensive genomic investigations. Tumor initiation and progression in hepatic tissues are frequently attributed to somatic mutations, which may result in similar phenotypic manifestations across different liver cancer subtypes. Over recent decades, a deeper understanding of the genetic and molecular aberrations involved in hepatocarcinogenesis has emerged. This evolving insight holds promise for the development of innovative therapeutic agents capable of modulating multiple molecular targets implicated in liver cancer progression. This chapter explores the pathophysiological mechanisms underpinning liver cancer, outlines traditional treatment modalities, and highlights the therapeutic potential of bioactive phytochemicals. These naturally occurring compounds, present in everyday dietary sources, represent a valuable adjunct or alternative to existing liver cancer therapies, potentially improving outcomes through multi-target engagement and minimal toxicity.
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    Smart Nanomaterials in Drug Delivery for Cancer Therapy
    (Springer, Singapore, 2025) Asim Rahman, Nazish Naseem, Amreen Fatima, Md. Faheem Haider
    In today’s world, one of the leading diseases people are facing is cancer, and liver cancer is one of them. Though various drugs acting via different mechanisms of action are present in the market as conventional formulations for the treatment of liver cancer they face substantial challenges regarding their bioavailability, low solubility and associated adverse effects which greatly limit their therapeutic efficacies. Nanotechnology has emerged as a promising tool for cancer therapy. Smart nanomaterials, in particular, have gained significant attention due to their unique properties, such as high surface area, biocompatibility, and the ability to be functionalized with targeting moieties. Smart nanomaterials can be designed to selectively deliver drugs to cancer cells, improve drug efficacy, and reduce toxicity. Various studies exhibit that nanocarriers can significantly increase drug bioavailability and increase solubility. The present chapter summarizes nanoformulations used in the treatment of liver cancer. It also highlights the available therapeutics in the market which is used for the treatment of liver cancer along with their side effects and drawbacks and how nanoformulation can overcome these drawbacks of present therapeutics.