Faculty Publications

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Scholarly Publications by Integral Academia

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    Biopolymer-based Chemotherapeutics: Combination Therapies and Synergistic Effects
    (Bentham Science, 2025) Rufaida Wasim, Tarique Mahmood, Saba Parveen, Aamir Anwar, Asad Ahmad
    Applications of nanotechnology have increased the importance of research and nanocarriers, which have revolutionized medication delivery in recent years to treat a range of diseases, including cancer. Due to its multidrug resistance to several chemotherapeutic treatments, cancer, one of the most dangerous diseases in the world, has drawn the attention of experts. Scientists have created a different way to deliver chemotherapeutic drugs to the desired location while reducing side effects and enhancing delivery efficacy on healthy cells by incorporating them into nanocarriers such as synthetic polymers, nanotubes, micelles, dendrimers, magnetic nanoparticles, Quantum Dots (QDs), lipid nanoparticles, nano-biopolymeric substances, etc. Nanotechnology applications have made research and nanocarriers—which have recently transformed drug delivery to treat a variety of illnesses, including cancer—even more crucial. One of the most deadly illnesses in the world, cancer, has caught the attention of scientists because of its multidrug resistance to several chemotherapeutic therapies. By integrating chemotherapeutic drugs into nanocarriers like synthetic polymers, nanotubes, micelles, dendrimers, magnetic nanoparticles, Quantum Dots (QDs), lipid nanoparticles, nano-biopolymeric substances, etc., researchers have developed an alternative method of delivering these medications to the intended site while minimizing side effects and improving delivery efficacy on healthy cells. Preclinical and clinical research on cancer treatment has yielded promising results. Biopolymers stand out as viable options for anticancer nano drug delivery systems due to their exceptional biocompatibility. Moreover, the presence of ligands in some biopolymers that are naturally present on the surface of human cells enables active targeting.
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    The Circadian System and Biological Rhythms
    (CRC Press, 2026) Rufaida Wasim, Elena Zaahu, Tarique Mahmood, Aamir Anwar, Abdulaziz S. Sacedan
    An important biological mechanism that controls the timing of many physiological and behavioral processes throughout the day is the circadian clock. The hypothalamic suprachiasmatic nucleus (SCN), the master clock that masters the rhythmic production of genes, hormones, and other functions, lies at the hub of this system. Hormone release, body temperature, metabolism, and the sleep-wake cycle are all regulated by circadian rhythms. These rhythms, which assist the body's internal timekeeping system stay in sync with the outside world, are regulated by both internal biological clocks and external environmental cues like light and darkness. Circadian rhythms ensure the body's physiological processes align with the day-night cycle, which is essential for maintaining optimal health. Sleep disorders, metabolic irregularities, cardiovascular ailments, and mental disorders may all result from disruptions to these cycles brought on by shift work, and extreme sleep deprivation. Studies have also connected the onset of chronic illnesses like diabetes and cancer to abnormalities of the circadian clock. Enhancing medical research and public health necessitates a perception of the molecular mechanisms underlying circadian rhythms and how they react to environmental stimuli. The devastating effects of circadian disruption may be debilitated by interventions like behavioral changes meant to maximize or restore circadian rhythms. This chapter discusses the circadian system's evolution, function, impact on biological cycles, and implications for both health and illness.
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    Synergism in Nutraceutical Formulations
    (Springer nature, 2025) Mohd Aftab Siddiqui; Mrunalini Gobinath, Sagarika Mukherjee, Rania I. M. Almoselhy, Afreen Usmani, Rajakumari Rajendran, Sabu Thomas, and Manisha Bihan
    Nutraceuticals are bioactive compounds or functional foods consumed to sustain nutrition and support disease prevention. Derived from nutrition and pharmaceuticals, the concept merges food science with therapeutic potential. Synergism in nutraceutical formulations arises when two or more bioactive agents interact to produce enhanced pharmacological or physiological outcomes that surpass the sum of their individual effects. This principle addresses key challenges of monotherapy: poor bioavailability, limited target specificity, and rapid metabolic degradation by enabling multicomponent, mechanistically complementary formulations. Recent innovations such as nano-encapsulation and codelivery systems further enhance absorption, stability, and efficacy of synergistic blends. This chapter provides a comprehensive overview of molecular and formulation-based synergism in nutraceuticals, focusing on mechanistic interactions, formulation challenges, and future directions toward supernutraceuticals that integrate advanced bioengineering and traditional dietary wisdom.
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    Chronotherapy in Cardiovascular Disease
    (Location Boca Raton, 2025) Zahra Sufwan, Javed Akhtar Ansari, Nortoji Khujamshukurov, Mohemmed Faraz Khan
    Chronotherapy, aligning medication timing with the body’s biological rhythms, shows promise in improving cardiovascular disease (CVD) treatment. By tailoring drug schedules to circadian patterns in blood pressure, heart rate, and coagulation, it enhances therapeutic effectiveness while reducing side effects. This approach is explored in managing conditions like hypertension, heart failure, myocardial infarction, and arrhythmias. The chapter explores how circadian rhythm disruptions impact cardiovascular health and disease progression. It highlights the pharmacokinetics and pharmacodynamics of cardiovascular drugs, emphasizing optimized dosing schedules. For instance, nighttime antihypertensives better manage morning blood pressure surges, while evening statin use aligns with peak cholesterol synthesis for improved lipid control. This chapter explores practical aspects of chronotherapy, including challenges like patient adherence and variability in circadian responses. It also highlights advancements in personalized chronotherapy, such as wearable devices and digital tools for monitoring rhythms, paving the way for customized treatment plans. This chapter examines the science of chronotherapy in cardiovascular care, providing healthcare professionals with insights on how strategic medication timing enhances patient outcomes. With increasing evidence of its benefits, chronotherapy could revolutionize cardiovascular treatment, offering more personalized and effective approaches for chronic conditions.
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    International Conference on Novel Paradigms in Pharmaceutical Sciences: An Approach for Healthier World (ICNPPS-2024)
    (Pedatrix Global Solutions, Lucknow, 2024) Javed Akhtar Ansari; Syed Misbahul Hasan, Juber Akhtar, Prof. Tarique Mahmood Ansari, Kuldeep Singh, Vaseem A. Ansari, Badruddeen, Poonam Kushwaha, Ahsan Ahmad Khan
    The Faculty of Pharmacy of Integral University organized two days International Conference on “Novel Paradigms in Pharmaceutical Sciences: an Approach for Healthier World”, dated 9-10 March, 2024. Pharmaceutical sciences have been evolving rapidly in recent years. The focus has shifted from traditional drug discovery and development to more innovative approaches that are aimed at improving patient outcomes. The goal of the conference was to bring together academics and researchers from all areas of pharmaceutical sciences and other related fields and to provide a potential platform for exchanging and updating your knowledge in pharmaceutical and health sciences research and innovation. It offered exciting scientific programs that covered all aspects of pharmaceutical sciences from its basics to their applications. The conference also gave attendees a clear knowledge of the problems caused by advance pharmaceuticals, as well as potential solutions. It was an excellent forum for students, postdoctoral fellows, established scientists, faculties, and industry delegates from India and abroad, to exchange ideas and expand their knowledge. It was an excellent occasion to meet researchers from India and across the globe and provided a platform to widen professional contact and create new opportunities, including establishing new collaborations. This strategic conference provided in-depth presentations and interactive sessions, for the possibility to network with like-minded professionals and discuss how to overcome the current challenges in pharmaceutical sciences. The conference was also been planned to have oral and poster presentation sessions from the academic and industry delegates, researchers, and other potential resource personnel.
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    Role of Medicinal Plant-Derived Nanoparticles Against Chronic Diseases
    (Springer, Cham, 2025) Mohd Aftab Siddiqui, Mohammad Saidurrahman, Afreen Usmani
    Medicinal herbs have been discovered to contain medicinal properties, and the development in nanotechnology has improved their efficiency toward healing chronic diseases. This chapter discusses the synthesis and use of nanoparticles (MPNPs) from medicinal plants for treating diseases like diabetes, cardiovascular disease, cancer, neurodegenerative diseases, and inflammation. These nanoparticles are more bioavailable, site-directed, and less systemically toxic, avoiding the limitations of conventional treatment. The primary mechanisms of action include antioxidant, anti-inflammatory, and antimicrobial activity, as well as modulating key cellular pathways. The chapter also emphasizes pioneering nanoparticle synthesis approaches, including green and biogenic synthesis, and highlights their benefits as scalable and eco-friendly. Stability concerns, regulatory implications, and clinical translation are also discussed, along with directions for future studies to maximize the potential of MPNPs in personalized medicine.
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    An Introduction to Bioprocessing and Industrial Bio-Manufacturing Foundation and Evolution
    (IGI Global Scientific Publishing, 2025) Rabin Debnath, Mohd Aftab Siddiqui, Tapoban Bordoloi, Izaz Hussain, Sneha Parbin, Mostafa Khursid Alam, Sachin Kumar, Shriyansh Srivastava, Rakesh Sahu
    This chapter highlights the transformative potential of bioprocessing and biomanufacturing as central forces in biotechnology, ecology, and medicine. Bioprocessing is the foundation of modern biotechnology because it actively employs biological systems to produce valuable compounds while simultaneously addressing urgent global challenges. Through carefully designed processes, bioprocessing mitigates climate change, strengthens ecosystem resilience, and responds to the escalating demands of global population growth by enabling sustainable production of food, medicines, and renewable energy.
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    Chronopharmacology: Time-Dependent Pharmacotherapy
    (CRC Press, 2025) Mohd Aftab Siddiqui, Afreen Usmani, Mohd Nazam Ansari
    Chronopharmacology: Time-Dependent Pharmacotherapy explores the cutting-edge science of tailoring drug administration to the body's natural biological rhythms, known as circadian rhythms. This comprehensive book provides healthcare professionals and researchers a deep understanding of how the timing of drug administration can impact therapeutic efficacy, safety, and patient outcomes. By integrating knowledge from pharmacology, chronobiology, and clinical medicine, the book offers both theoretical insights and practical guidelines for applying chronopharmacology in the treatment of diseases like cardiovascular disorders, cancer, and sleep-related conditions. Through case studies and the latest research on circadian-based drug delivery systems, this text is an invaluable resource for clinicians aiming to optimize patient care and researchers exploring new frontiers in personalized medicine.
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    Gut Microbiota and Colorectal Cancer Pathogenesis
    (Humana, Cham, 2025) Anas Islam, Badruddeen, Mohammad Irfan Khan, Mohsin Vahid Khan, Yusuf Asad
    This chapter explores the complex relationship between the gut microbiota and the pathogenesis of colorectal cancer (CRC), highlighting the role of microbial dysbiosis in promoting inflammation, DNA damage, and immune dysregulation. It reviews key pro-carcinogenic bacteria, such as Fusobacterium nucleatum, Bacteroides fragilis, and pks+ Escherichia coli, which contribute to tumor initiation and progression. The chapter also discusses the protective effects of beneficial microbes like Lactobacillus and Bifidobacterium, which help maintain gut health and inhibit carcinogenesis. Therapeutic strategies aimed at modulating the gut microbiota, including dietary interventions, probiotics, prebiotics, fecal microbiota transplantation (FMT), and postbiotics, are examined for their potential in CRC prevention and treatment. Finally, future directions in personalized microbiome-based therapies, diagnostic biomarkers, and the challenges facing clinical translation of gut microbiota research are addressed. The chapter emphasizes the growing importance of targeting the microbiome in CRC management to enhance prevention, diagnosis, and therapeutic outcomes.
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    Antimicrobial Resistance: An Unknown Threat to Humankind
    (Integrated Publications, 2024) Sahil Hussain, Arun Kumar, Kuldeep Singh, Shom Prakash Kushwaha, Mohd. Mursal, Mohd. Shainoor
    With resistance found to every antibiotic now in clinical use and only a handful of innovative treatments in the development, antibiotic resistance is a worldwide health disaster. Understanding the molecular mechanisms that bacteria use to withstand the effects of antimicrobials is essential for identifying global patterns of resistance, optimising the use of existing medications, designing new medications that are less likely to develop resistance, and developing cutting-edge methods to combat resistance. In this review, we look at recent developments in our knowledge of how resistance genes affect the biology of the host, as well as new structural information on important molecular processes that underlie resistance, various mechanism of resistance and method of destruction of antibiotic through variety of different enzymatic action and other methods involved such as efflux and conformational changes that are adopted by the bacteria and other microorganism to combat antibiotics. Finally, we go over how we can apply this knowledge to create the newest antimicrobial treatments.