Modulating CYP450 Isozyme to Prevent DB[a,l]P-Induced Mammary Cancer

Abstract

The general mechanism of cancer encompasses the metabolism of carcinogens to highly electrophilic metabolites capable of binding to DNA and other macromolecules, thereby initiating cellular transformation. As the carcinogenesis mechanism is highly complex, involving diverse cellular mechanisms in cancer promotion and progression, elucidating the various underlying processes presents a significant challenge. Extensive research into the multifaceted nature of cancer initiation and development, along with associated risk factors and modulators, has resulted in the identification of numerous molecular and cellular markers specific to different cancer types. Nearly all exogenous compounds entering cells are metabolized by phase I and phase II enzymes.