Therapeutic Impact of Exosomes in Stroke and Transient Ischemic Attack

Abstract

Stroke and transient ischemic attack (TIA) are debilitating neurological conditions characterized by a sudden disruption of blood flow to the brain, resulting in tissue damage and functional impairments. Despite extensive research efforts, effective therapeutic interventions for stroke and TIA remain limited. However, recent advancements in the field of exosome-based therapeutics have shown promising potential for the treatment of these brain disorders. Exosomes, small extracellular vesicles secreted by various cell types, have emerged as key mediators of intercellular communication, owing to their ability to transport bioactive molecules and modulate cellular functions. This chapter discusses the therapeutic effects of exosomes in stroke and TIA, elucidating the mechanisms underlying exosome-mediated neuroprotection. Furthermore, the chapter delves into the challenges associated with exosome-based therapies, including limitations and barriers to clinical translation. Strategies to overcome these challenges are discussed, along with emerging trends and future directions in exosome research for stroke and TIA. In conclusion, this chapter highlights the therapeutic impact of exosomes in stroke and TIA, underscoring their potential as a novel and promising avenue for therapeutic intervention. By addressing the current knowledge gaps and exploring future research directions, this chapter aims to contribute to the advancement of exosome-based therapies in clinical practice.