Pulmonary drug delivery of lipid-based formulations via nebulizers

Abstract

Nebulizers are medical equipment that transform liquid drugs into inhaled aerosols. They are widely utilized in the management of respiratory conditions such cystic fibrosis, asthma, and chronic obstructive pulmonary disease (COPD). Compared with alternative pulmonary drug delivery methods, lipid-based nebulizers have several benefits, such as the capacity to encapsulate medications and shield them from deterioration, as well as their safety and biocompatibility profiles. The goal is to emphasize the potential of lipid-based nebulizers as a viable drug delivery technology for the treatment of respiratory disorders and to explain the benefits of employing lipid-based formulations for pulmonary medication delivery. The chapter discusses the several types of nebulizers and their applications, as well as formulation development, nebulizer performance, and clinical applications. The importance of this chapter stems from its ability to aid researchers and physicians in the development and deployment of lipid-based nebulizers for pulmonary medication delivery, resulting in enhanced treatment choices for patients with respiratory disorders.