Rauwolfia serpentina (L.) Benth. ex Kurz

Abstract

Rauwolfia serpentina, native to the Indian subcontinent and Southeast Asia, has been used for centuries in traditional medicine systems of Ayurveda and Unani. R. serpentina is an evergreen, perennial undershrub thriving in tropical and subtropical environments with moist, well-drained soils and moderate to high rainfall. Its roots, containing indole alkaloids, have been used as a crude drug to treat hypertension, mental disorders, and snake bites. The isolation of reserpine from R. serpentina, in the mid-twentieth century, revolutionized hypertension treatment and contributed to modern neuropsychopharmacology. The plant’s complex chemical composition of over 50 alkaloids, flavonoids, tannins, and other bioactive compounds, is influenced by geographic location, age, and seasonal changes. This chemical diversity enhances its therapeutic potential but challenges quality control and standardization. The transition from traditional use to modern medicine exemplifies reverse pharmacology, where empirical observations guide drug discovery. Modern research has validated claims regarding the plant’s sedative, antipsychotic, and gastrointestinal benefits, while advanced techniques have allowed the refinement of its therapeutic applications. R. serpentina remains important in indigenous healthcare and a promising source for future drug development.