Abdul HafeezShazia Afzal Usmani2024-10-242023978-1-80356-367-110.5772/intechopen.106374http://136.232.12.194:4000/handle/123456789/912Book: Liposomes - Recent Advances, New Perspectives and Applications Edited by Rajeev TyagiDiseases related to the brain are causing a huge problem worldwide. Different drug formulations are available for the management of brain-related disorders, but due to less drug availability for the brain and non-specificity, it becomes difficult to completely cure life-threatening brain disorders. The blood-brain barrier (BBB) restricts the entry of drug molecules/drug-loaded carriers because of the presence of various efflux transporters and drug inactivating enzymes. Researchers have identified an intranasal route for direct delivery to the brain, bypassing BBB. Nanotechnology-enabled lipid-based drug carrier systems have shown potential for the management of brain diseases through nose-to-brain delivery. Liposomes are the most extensively investigated carrier systems because of biocompatibility, controlled release characteristics, easy surface modification, and biodegradability. This chapter highlights the important aspects of nose-to-brain delivery and strategies for enhancing the availability of drugs through liposomes in the management of different brain-related diseases.en-USliposomesnanotechnologybrain tumorParkinson’s diseasetargeted deliveryPHARMACYBook chapter