Vishal Agarwal2026-04-252025978-81-986254-1-0http://136.232.12.194:4000/handle/123456789/1792Advances in Biosciences: Emerging Trends and Innovations Editor(s): Dr. B. Suresh Dr. P. Baby shakila, Dr. S. RajKumar, Dr. K. RajaganeshComplex diseases, including diabetes, cardiovascular disorders, cancer, and neurological conditions, result from intricate interactions among numerous genetic and environmental factors. Unlike monogenic diseases, complex disorders involve polygenic contributions, making the identification of causal variants particularly challenging. With the advent of high-throughput technologies such as genome-wide association studies (GWAS), whole-genome sequencing (WGS), and integrative multi-omics, researchers have made substantial progress in identifying genetic variants associated with disease phenotypes. However, a significant proportion of heritability remains unexplained, and many identified variants lie in non-coding regions, complicating functional interpretation. This paper explores the methodologies used to uncover genetic contributions to complex diseases, discusses findings from recent literature, highlights the significance of functional genomics and systems biology, and proposes future directions for more inclusive and mechanistically insightful studies. Bridging the gap between genetic discovery and clinical application remains a central goal of current genomic research.en-UScomplex diseasesgenetic variantsGWASwhole-genome sequencingpolygenic risksystems geneticsmulti-omicsgene-environment interactionBook chapter