Mohd Akil, Iqbal Azad, Abdul Rahman Khan, Naseem Ahmad2026-09-232026https://doi.org/10.5281/zenodo.21356314http://136.232.12.194:4000/handle/123456789/2213Conference THE UZBEKISTAN–CHINA INTERNATIONAL SYMPOSIUM ON "CURRENT ISSUES IN THE CULTIVATION AND UTILIZATION OF MEDICINAL PLANTS" , Tashkent, 18-19 June, 2026The present work reports the synthesis of novel chalcone‐derived compounds obtained via simple condensation of chalcone derivatives with phenyl hydrazine. Their design, preparation, and biological assessment are described in detail. Structural elucidation was confirmed by FTIR, 1H NMR, 13C NMR, and HRMS analyses. In‐silico ADMET profiling, carried out using AdmetLab 3.0 and SwissADME, indicated favorable pharmacokinetic and toxicity parameters, closely resembling those of reference agents Amphotericin B and Ciprofloxacin. These findings underscore the promise of chalcone scaffolds as versatile templates for antibacterial drug development.en-USSynthesisHeterocyclesIn silicoADMETPyrazoleArticle