Peptidomimetics in Organic and Medicinal Chemistry: the art of transforming peptides in drugs
Trabocchi, Andrea,
Peptidomimetics in Organic and Medicinal Chemistry: the art of transforming peptides in drugs [Text] Andrea Trabocchi, Antonio Guarna. - xix, 288 pages : illustrations ; 25 cm
Includes bibliographical references and index.
"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--Provided by publisher. "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"--Provided by publisher.
9781119950608
2013048681
Peptide drugs.
Proteins--Therapeutic use.
Drugs--Design.
RS431.P38 / T73 2014
615.1/9 / TRA/P
Peptidomimetics in Organic and Medicinal Chemistry: the art of transforming peptides in drugs [Text] Andrea Trabocchi, Antonio Guarna. - xix, 288 pages : illustrations ; 25 cm
Includes bibliographical references and index.
"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--Provided by publisher. "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"--Provided by publisher.
9781119950608
2013048681
Peptide drugs.
Proteins--Therapeutic use.
Drugs--Design.
RS431.P38 / T73 2014
615.1/9 / TRA/P
