TY  - BOOK
AU  - Trabocchi,Andrea
AU  - Guarna,Antonio
TI  - Peptidomimetics in Organic and Medicinal Chemistry: the art of transforming peptides in drugs
SN  - 9781119950608
AV  - RS431.P38 T73 2014
U1  - 615.1/9 23
KW  - Peptide drugs
KW  - Proteins
KW  - Therapeutic use
KW  - Drugs
KW  - Design
N1  - Includes bibliographical references and index
N2  - "A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--Provided by publisher; "Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"--Provided by publisher
ER  -