000			02169nam a22003137a 4500
003			OSt
005			20200819135513.0
008			131209s2014 enka 001 0 eng d
010			_a2013048681
020			_a9781119950608
040			_aIUL-LIB _cIUL-LIB
041			_aEnglish
042			_apcc
050		4	_aRS431.P38 _bT73 2014
082	0	0	_a615.1/9 _223 _bTRA/P
084			_aSCI013050 _2bisacsh
100	1		_aTrabocchi, Andrea, _eauthor.
245	1	0	_aPeptidomimetics in Organic and Medicinal Chemistry: the art of transforming peptides in drugs _cAndrea Trabocchi, Antonio Guarna. _h[Text]
300			_axix, 288 pages : _billustrations ; _c25 cm
504			_aIncludes bibliographical references and index.
520			_a"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--Provided by publisher.
520			_a"Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"--Provided by publisher.
650		0	_aPeptide drugs.
650		0	_aProteins _xTherapeutic use.
650		0	_aDrugs _xDesign.
700	1		_aGuarna, Antonio, _eauthor.
942			_2ddc _cTB
999			_c28381 _d28381